| Box-Behnken效应面法优化石杉碱甲纳米结构脂质载体处方 |
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| 引用本文： | 杨春荣；孙,忻；赵秀峰；胡海洋；乔明曦；陈大为.Box-Behnken效应面法优化石杉碱甲纳米结构脂质载体处方[J].沈阳药科大学学报,2011,28(10):769-774. |
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| 作者姓名： | 杨春荣；孙 忻；赵秀峰；胡海洋；乔明曦；陈大为 |
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| 作者单位： | (1.佳木斯大学 药学院，黑龙江 佳木斯 154007；2. 牡丹江医学院 附属医院肿瘤科，黑龙江 牡丹江157011；3. 沈阳药科大学 药学院，辽宁 沈阳110016) |
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| 基金项目： | 佳木斯大学面上资助项目(L2009-107) |
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| 摘 要： | 目的采用Box-Behnken效应面法筛选石杉碱甲纳米结构脂质载体最佳处方。方法采用熔融超声-高压匀质法制备石杉碱甲纳米结构脂质载体,分别以混合脂质(X1)、混合乳化剂(X2)和脂药比(X3)为考察对象,以粒径(Y1)、包封率(Y2)和载药量(Y3)为评价指标,利用三因素三水平Box-Behnken效应面设计法筛选石杉碱甲纳米结构脂质载体的最佳处方。结果按最优处方制备的纳米粒粒径为(121.67±3.21)nm、包封率为(89.18±0.28)%、载药量为(1.46±0.05)%,与预测值偏差均小于5%。结论采用Box-Behnken效应面法优化石杉碱甲纳米结构脂质载体处方是有效、可行的。
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| 关 键 词： | 石杉碱甲 纳米结构脂质载体 熔融超声-高压匀质法 Box-Behnken效应面法 |
| 收稿时间： | 2011-2-28 |
| 修稿时间： | 2011-7-28 |
Formulation optimization of huperzine A loaded nanostructured lipid carriers by Box-Behnken experimental design |
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| YANG Chun-Rong,SUN Xin,ZHAO Xiu-Feng,HU Hai-Yang,QIAO Ming-Xi,CHEN Da-Wei.Formulation optimization of huperzine A loaded nanostructured lipid carriers by Box-Behnken experimental design[J].Journal of Shenyang Pharmaceutical University,2011,28(10):769-774. |
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| Authors: | YANG Chun-Rong SUN Xin ZHAO Xiu-Feng HU Hai-Yang QIAO Ming-Xi CHEN Da-Wei |
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| Affiliation: | (1. College Pharmacy of Jiamusi University, Jiamusi 154007, China; 2. Department of Oncology, Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157011, China; 3. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China ) |
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| Abstract: | Objective To optimize the formulation of huperzine A loaded nanostructured lipid carriers by Box-Behnken design. Methods Huperzine A loaded nanostructured lipid carriers were prepared by melt ultrasonication-high pressure homogenization method.A three factor,three-level Box-Behnken design was employed,with the amount of the mixed lipid(X1),emulsifier mixture concentration(X2)and lipid/drug ratio(X3) as the independent variables.The dependent variables were the particle size(Y1),entrapment efficiency(Y2) and... |
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| Keywords: | huperzine A nanostructured lipid carrier melt ultrasonication-high pressure homogenization method Box-Behnken design |
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