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| N-琥珀酰壳聚糖纳米粒的制备及体外评价 | |
| 引用本文： | 颜承云,晏马成,陈大为,谷继伟,乔名曦,赵秀丽.N-琥珀酰壳聚糖纳米粒的制备及体外评价[J].沈阳药科大学学报,2007,24(9):521-523,581. |
| 作者姓名： | 颜承云 晏马成 陈大为 谷继伟 乔名曦 赵秀丽 |
| 作者单位： | 1. 沈阳药科大学,药学院,辽宁,沈阳,110016 2. 上海浦南医院,药剂科,上海,200122 3. 佳木斯大学,第一附属医院,黑龙江,佳木斯,154000 4. 沈阳药科大学药学院,辽宁,沈阳,110016 |
| 摘 要： | 目的制备N-琥珀酰壳聚糖纳米粒并对其进行体外评价。方法采用乳化溶剂挥发法制备N-琥珀酰壳聚糖纳米粒;以包封率、载药量及粒径为指标,采用正交设计法对处方进行优化;考察其理化特征及体外释药行为。结果纳米粒包封率及载药量分别为62.36%和18.98%,平均粒径及zeta电位分别为(206.6±64.7)nm和(-27.2±0.2)mV;1 h药物释放达到45%,随后药物的释药行为是一个缓释过程。结论作者采用乳化溶剂挥发法成功制得N-琥珀酰壳聚糖纳米粒。该方法制得纳米粒包封率较高,制备工艺简单。 |
| 关 键 词： | N-琥珀酰壳聚糖 纳米粒 理化特征 体外释放 |
| 文章编号： | 1006-2858（2007）09-0521-03 |
| 修稿时间： | 2006-12-06 |
Preparation and in vitro evaluation of N-succinyl-chitosan(Suc-Chi)nanoparticles |
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| YAN Cheng-yun,YAN Ma-cheng,CHEN Da-wei,GU Ji-wei,QIAO Ming-xi,ZHAO Xiu-li.Preparation and in vitro evaluation of N-succinyl-chitosan(Suc-Chi)nanoparticles[J].Journal of Shenyang Pharmaceutical University,2007,24(9):521-523,581. | |
| Authors: | YAN Cheng-yun YAN Ma-cheng CHEN Da-wei GU Ji-wei QIAO Ming-xi ZHAO Xiu-li |
| Affiliation: | 1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China ; 2. Medicament Administrative, Shanghai Punan Hospital, Shanghai 200122, China ;3. First Affiliated Hospital of Jiamusi of University, Jiamusi 154000, China |
| Abstract: | Objective To prepare 5-fluorouracil loaded N-Succinyl-chitosan nanoparticles(5-FU-Suc-Chi/NPs) and investigate their properties in vitro.Methods 5-FU-Suc-Chi/NPs were prepared by an emulsification solvent diffusion method.With the entrapment efficiencies as references,the formulation was optimized by orthogonal design.Results The 5-FU entrapment efficiency of the nanoparticles and their loading capacity were 62.36% and 18.98% respectively.The Suc-Chi nanoparticles have a particle diameter(Z-average) of(206.6±64.7) nm and a negative zeta potential of(-27.2±0.2) mV.A burst release was found in the initial 1 hour followed by a continuous sustained release in vitro for 5-FU-Suc-Chi/NPs.Conclusions The entrapment efficiency of the nanoparticles is high and the preparation method is simple. |
| Keywords: | N-succinyl-chitosan nanoparticles physico-chemical characterization in vitro release |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
