有丝分裂关键激酶抑制剂的研究进展

目的综述有丝分裂关键激酶抑制剂近年来的研究进展。方法根据已报道的有丝分裂中关键激酶抑制剂的文献,将对有丝分裂过程中与肿瘤发生联系密切的激酶抑制剂,如Aurora激酶抑制剂、CDK(cyclin-dependent kinase)激酶抑制剂、PLK(Polo-like kinase)激酶抑制剂、CHK(check-point kinase)激酶抑制剂等目前的研究进展进行综述。结果有丝分裂关键激酶抑制剂已在临床前研究及临床研究中显示出很好的抗肿瘤活性。结论随着研究的不断深入,有丝分裂关键激酶抑制剂将在肿瘤治疗中发挥更大的作用。

Progress on the research of key kinase inhibitors in mitosis

Objective To review the recent progress on the research of key kinase inhibitors in mitosis. Method According to the references to the key kinase inhibitors in mitosis reported, the kinase inhibitors was introduced closely related to the occurrence of the cancer in the progress of mitosis, such as Aurora kinase inhibitors, CDK (cyclin-dependent kinase) inhibitors, PLK(Polo-like kinase) inhibitors and CHK(checkpoint kinase) inhibitors. Result The potent anti-tumor activity of key kinase inhibitors in mitosis had been revealed in the preclinical and clinical research. Conclusion With the further research, key kinase inhibitors in mitosis shows more significant roles in the therapy of cancer.