Twist、Snail蛋白在喉鳞状细胞癌中的表达及其临床意义

目的 探讨Twist、Snail蛋白在喉鳞状细胞癌（喉鳞癌）组织中的表达及其临床意义.方法 应用免疫组织化学法检测60例喉鳞癌组织、30例癌旁组织中Twist、Snail蛋白的表达情况.结果 喉鳞癌组织中Twist的阳性表达为68.3％（41/60）,Snail的阳性表达为71.7％ （43/60）,均显著高于癌旁组织中的表达率；在喉鳞癌组织中Twist、Snail蛋白的表达之间存在显著正相关,相关系数（r）为0.529（P ＜0.01）.结论 喉鳞癌组织中存在Twist、Snail蛋白的高表达,两者的联合表达能增加肿瘤细胞侵袭力,促进喉鳞癌的浸润、转移.

Expression and clinical significance of Twist and Snail in laryngeal squamous cell carcinoma

Objective To study the expression and clinical significance of Twist and Snail in laryngeal squamous cell carcino- ma. Methods Expression of Twist and Snail was detected in 60 cases of laryngeal squamous cell carcinoma tissues and 30 cases of ad- jacent tissues by immunohistochemistry. Results The positive Twist expression was 68.3% in laryngeal squamous cell carcinoma,and the positive Snail was 71.7%, showing a significantly difference in the expression of Twist and Snail between carcinoma and adjacent tissues. There was a significant correlation between the expressions of Twist and Snail in laryngeal squamous cell carcinoma, r = 0. 529, P 〈 0.01. Conclusion The overexpression of Twist and Snail protein were found in laryngeal squamous cell carcinoma. Their co-ex- pression could contribute to the invasion and metastasis in laryngeal squamous cell carcinoma. They were valuable molecular markers to be used for monitoring the disease.