| 成骨细胞的功能与损伤和骨质疏松的防治 |
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| 引用本文： | 刘扬捷,龚晓健,王永庆.成骨细胞的功能与损伤和骨质疏松的防治[J].江苏药学与临床研究,2019,27(3):201-205. |
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| 作者姓名： | 刘扬捷 龚晓健 王永庆 |
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| 作者单位： | 中国药科大学,中国药科大学,南京医科大学第一附属医院 |
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| 基金项目： | 国家自然科学基金（面上项目）（81673515） |
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| 摘 要： | 骨质疏松是一种全身性骨骼疾病，导致骨折风险增加。成人的骨量通过破骨细胞的骨吸收和成骨细胞的骨形成作用来维持动态平衡，治疗骨质疏松症的理想策略是抑制破骨细胞的骨吸收和/或增强成骨细胞的骨形成功能。目前针对保护成骨细胞及增强其功能的骨质疏松疗法相对较少。因此，本文针对成骨细胞相关功能蛋白、各种细胞损伤机制（内质网应激、氧化应激、机械过载、微小RNA和长链非编码RNA的影响等）及骨质疏松的治疗与预防作一综述，以期为针对增强成骨细胞功能的骨质疏松治疗策略提供新思路。
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| 关 键 词： | 骨质疏松 成骨细胞 内质网应激 |
| 收稿时间： | 2018/12/29 0:00:00 |
| 修稿时间： | 2019/6/11 0:00:00 |
Function and Injury of Osteoblasts and Prevention and Treatment of Osteoporosis |
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| Liu Yang-jie,Gong Xiao-jian and Wang Yong-qing.Function and Injury of Osteoblasts and Prevention and Treatment of Osteoporosis[J].Jiangsu Pharmacertical and Clinical Research,2019,27(3):201-205. |
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| Authors: | Liu Yang-jie Gong Xiao-jian and Wang Yong-qing |
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| Affiliation: | China Pharmaceutical University,China Pharmaceutical University,First Af?liated Hospital of Nanjing Medical University |
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| Abstract: | Osteoporosis is a systemic bone disease that increases the risk of fracture. Bone mass of adults maintains homeostasis through osteoclast resorption and osteogenesis by osteoblasts. The ideal strategies for treating osteoporosis are to inhibit the bone resorption by osteoclasts or increase the bone formation by osteoblasts. Currently, there are few therapies aimed at protecting osteoblasts and enhancing their functions. Therefore, this article reviews the functional proteins and cell damage mechanisms of osteoblasts and the treatment and prevention of osteoporosis, to provide new ideas for osteoporosis treatments through enhancing osteoblast functions. |
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| Keywords: | Osteoporosis Osteoblasts Endoplasmic reticulum stress |
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