| 喷雾干燥技术在蛋白、多肽类药物微球制备中的应用 |
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| 引用本文： | 白洁,何应.喷雾干燥技术在蛋白、多肽类药物微球制备中的应用[J].药学进展,2007,31(7):298-302. |
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| 作者姓名： | 白洁 何应 |
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| 作者单位： | 天津大学药物科学与技术学院,天津,300072 |
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| 摘 要： | 按照不同的常用载体材料（聚乳酸类和壳聚糖类），分类综述应用喷雾干燥技术制备蛋白、多肽类药物微球的研究进展，主要介绍和比较了溶液，喷雾干燥、乳剂，喷雾干燥、喷雾冷冻干燥、喷雾液中冷冻及低温喷雾提取等制备工艺的特点。
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| 关 键 词： | 喷雾干燥 微球 聚乳酸 壳聚糖 蛋白 多肽 |
| 文章编号： | 1001-5094（2007）07-0298-05 |
| 收稿时间： | 2007-04-12 |
| 修稿时间： | 2007-04-12 |
Application of Spray Drying Technique to Preparation of Protein-and Peptide-loaded Microspheres: a Review |
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| BAI Jie,HE Ying.Application of Spray Drying Technique to Preparation of Protein-and Peptide-loaded Microspheres: a Review[J].Progress in Pharmaceutical Sciences,2007,31(7):298-302. |
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| Authors: | BAI Jie HE Ying |
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| Affiliation: | School of Pharmaceuticals Science and Technology, Tianjin University, Tianjin 300072, China |
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| Abstract: | According to different kinds of common carrier materials: PLA,PLGA and chitosan,the advances in application of spray drying technique to preparation of protein-and peptide-loaded microspheres were reviewed classifiedly.And the characteristics of major spray drying techniques,such as solution/spraydrying,emulsion/spray-drying,spray freeze drying,spray freezing into liquid and cryogenic spray extraction,were introduced and compared. |
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| Keywords: | Spray drying Microspheres PLA Chitosan Protein Polypeptide |
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