盐酸瑞芬太尼的波谱学数据和结构分析

目的]通过波谱学数据对盐酸瑞芬太尼的化学结构进行分析。方法]测定盐酸瑞芬太尼的红外吸收光谱(IR)、核磁共振氢谱(^1HNMR)、氢-氢相关谱(^1H-^1HCOSY)、核磁共振碳谱(^13CNMR)、DEPT谱、碳-氢相关谱(^13C-^1 HCOSY)、质谱(MS)及单晶X-衍射图谱，进行结构分析和讨论。结果]该化合物的^1HNMR和^13CNMR谱的所有谱峰均有合理的归属，其IR吸收峰所对应的官能团振动形式、MS的分子离子峰和主要碎片峰以及单晶X-衍射的结构均能得到合理的解释。结论]上述各种图谱分析数据均能与盐酸瑞芬太尼的结构式相吻合。

Spectral Data and Structural Analysis of Remifentanil Hydrochloride

To analyze the structure of remifentanil hydrochloride by spectral data. The spectra of IR, 1HNMR, 1H 1H COSY, 13 CNMR,DEPT, 13 C 1H COSY,MS and crystal X ray of remifentanil hydrochloride were determined and interpreted. All the 1HNMR and 13 CNMR chemical shifts were assigned rationally. The peaks of functional group vibrations (IR), the molecular ion peak and main fragment peaks (MS) and the structure from crystal X ray were all explained reasonably. CONCLUSION]The above analytical data of all kinds of spectra coincided with the structure of remifentanil hydrochloride.