| 吲哚咔唑类化合物对肿瘤相关酶的抑制作用 |
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| 引用本文： | 朱冰,尤启冬,翟富民,李志裕.吲哚咔唑类化合物对肿瘤相关酶的抑制作用[J].药学进展,2004,28(4):154-158. |
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| 作者姓名： | 朱冰 尤启冬 翟富民 李志裕 |
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| 作者单位： | 中国药科大学药学院,江苏,南京,210009 |
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| 摘 要： | 近年来，吲哚咔唑类化合物Staurosporine及其衍生物对肿瘤相关酶活性的抑制作用得到了广泛的研究此类化合物对蛋白激酶C、细胞周期蛋白依赖激酶、检测点激酶等都具有较好的抑制作用，并能抑制肿瘤细胞增殖因此可用于肿瘤的治疗。
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| 关 键 词： | 吲哚咔唑类化合物 肿瘤相关酶 蛋白激酶C 细胞周期蛋白依赖激酶 检测点激酶 细胞增殖 |
| 文章编号： | 1001-5094(2004)04-0154-05 |
| 修稿时间： | 2003年12月5日 |
Indolocarbazoles as Potent Inhibitors of Kinases Relative to Tumor |
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| ZHU Bing,YOU Qi dong ,ZHAI Fu ming,LI Zhi yu.Indolocarbazoles as Potent Inhibitors of Kinases Relative to Tumor[J].Progress in Pharmaceutical Sciences,2004,28(4):154-158. |
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| Authors: | ZHU Bing YOU Qi dong ZHAI Fu ming LI Zhi yu |
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| Affiliation: | ZHU Bing,YOU Qi dong *,ZHAI Fu ming,LI Zhi yu |
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| Abstract: | Indolocarbazole compounds, such as staurosporine and its derivatives, as potent kinase inhibitors have been studied comprehensively. Besides inhibiting protein Kinase C very well, they show potential bioactivities against Cyclin dependent kinase and Checkpoint kinase, and cell proliferation. Here a review is given to introduce the recent studies about the antitumor activity of indolocarbazoles by inhibiting kinases relative to cancer |
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| Keywords: | Indolocarbazole Tumor Kinase Inhibition |
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