| 糖尿病肾病的发生发展机制及药物控制的可能途径 |
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| 引用本文： | 高洁,戴德哉,丁选胜,戴茵.糖尿病肾病的发生发展机制及药物控制的可能途径[J].药学进展,2012,36(5):193-199. |
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| 作者姓名： | 高洁 戴德哉 丁选胜 戴茵 |
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| 作者单位： | 中国药科大学药理研究室,江苏南京,210009 |
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| 摘 要： | 糖尿病肾病是糖尿病的常见并发症,也是引起终末期肾病的最主要因素。其发生发展过程可能涉及多种机制,故需经多途径治疗。综述导致糖尿病肾病进展的可能机制及药物控制的可能途径,为进行基础研究、新药研发以及阻止糖尿病肾病的恶化提供依据。
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| 关 键 词： | 糖尿病肾病 内皮系统 氧化应激 内质网应激 p66shc基因 |
Development Mechanisms of Diabetic Nephropathy and the Possible Therapeutic Ways |
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| GAO Jie
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DAI De-zai
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DING Xuan-sheng
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DAI Yin.Development Mechanisms of Diabetic Nephropathy and the Possible Therapeutic Ways[J].Progress in Pharmaceutical Sciences,2012,36(5):193-199. |
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| Authors: | GAO Jie DAI De-zai DING Xuan-sheng DAI Yin |
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| Affiliation: | (Research Division of Pharmacology,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | The diabetic nephropathy is a common complication of diabetes,and it is also the most important cause of end-stage renal disease.Its development may involve multiple mechanisms,therefore,it needs a treatment through various ways.The possible mechanism leading to the progress of diabetic nephropathy and the approaches of drug therapy were reviewed,providing a basis for conducting the basic research,developing new drugs and preventing the diabetic nephropathy from deteriorating into end-stage renal disease. |
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| Keywords: | diabetic nephropathy endothelial system oxidative stress endoplasmic reticulum stress p66shc gene |
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