| 定量核磁共振技术及其在药学领域中的应用进展 |
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| 引用本文： | 于小波,沈文斌,相秉仁.定量核磁共振技术及其在药学领域中的应用进展[J].药学进展,2010,34(1):17-23. |
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| 作者姓名： | 于小波 沈文斌 相秉仁 |
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| 作者单位： | 中国药科大学分析测试中心,江苏,南京,210009 |
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| 摘 要： | 综述定量核磁共振技术的基本原理以及在新药研发中的应用进展。定量核磁共振作为一种定量分析方法，专属性强、准确快捷，可与其他定量方法相互补充，用于新药研发的诸多环节，如药品质量控制、候选药物纯度测定及药物代谢研究等，在药学领域有很好的应用前景。
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| 关 键 词： | 定量核磁共振 质量控制 药物代谢物 新药研发 |
Advances in Application of Quantitative Nuclear Magnetic Resonance Technique in Pharmaceutical Field |
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| YU Xiao-bo,SHEN Wen-bin,XIANG Bing-ren.Advances in Application of Quantitative Nuclear Magnetic Resonance Technique in Pharmaceutical Field[J].Progress in Pharmaceutical Sciences,2010,34(1):17-23. |
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| Authors: | YU Xiao-bo SHEN Wen-bin XIANG Bing-ren |
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| Affiliation: | YU Xiao-bo,SHEN Wen-bin,XIANG Bing-ren(Center for Instrumental Analysis,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | The principle of quantitative nuclear magnetic resonance (QNMR) technique and the advances in its applications within new drug R&D were reviewed.As a well-developed quantitative analysis method,QNMR is of high specificity and accuracy.It can be used to complement with other quantitative methods in new drug R&D,such as quality control of pharmaceuticals,purity determination of drug candidates,as well as the analysis of drug metabolites.It has a promising future in pharmaceutical field. |
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| Keywords: | QNMR quality control drug metabolite new drug research and development |
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