| 4＂-0-取代红霉素衍生物的研究进展 |
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| 引用本文： | 田鑫,毕小玲.4＂-0-取代红霉素衍生物的研究进展[J].药学进展,2012,36(11):481-486. |
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| 作者姓名： | 田鑫 毕小玲 |
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| 作者单位： | 中国药科大学药物化学教研室,江苏 南京,210009 |
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| 摘 要： | 随着大环内酯类抗生素广泛应用于临床，细菌耐药性的问题日趋严重，因此，开发对耐药菌有效的第3代红霉素衍生物成为目前的研究热点。综述红霉素分子上克拉定糖4＂位羟基结构修饰的研究进展，并介绍了若干个对耐药菌具有优良抗菌活性的新型4＂-0-取代红霉素衍生物。
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| 关 键 词： | 红霉素 细菌耐药性 结构修饰 抗菌活性 |
Recent Progress in Research on 4"-O-Substituted Erythromycin Derivatives |
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| TIAN Xin
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BI Xiao-ling.Recent Progress in Research on 4"-O-Substituted Erythromycin Derivatives[J].Progress in Pharmaceutical Sciences,2012,36(11):481-486. |
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| Authors: | TIAN Xin BI Xiao-ling |
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| Affiliation: | (Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | The therapeutic utility of macrolides has led to rapid increases in the resistance rates of bacteria isolated clinically. The third-generation erythromycin derivatives overcoming bacterial resistance are the hot research topic. The recent progress in research on the C-4＂ modification of 14- and 15-mem- bered semisynthetic erythromycin and the antimicrobial activity of the related derivatives was reviewed. Several promising 4＂-O-substituted erythromycin derivatives with a high activity against resistant strains were also introduced. |
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| Keywords: | erythromycin bacterial resistance structure modification antibacterial activity |
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