| 基因多态性与药物不良反应发生风险的相关性及其临床证据 |
| |
| 引用本文： | 李玉娇,初亚男,黄晓晖,张婕妤,周国华.基因多态性与药物不良反应发生风险的相关性及其临床证据[J].药学进展,2021(2):100-111. |
| |
| 作者姓名： | 李玉娇 初亚男 黄晓晖 张婕妤 周国华 |
| |
| 作者单位： | 东部战区总医院临床药学科 |
| |
| 摘 要： | 药物不良反应(ADR)是临床用药中常常出现的难题,不但影响药效,还严重威胁患者的生命安全。随着药物基因组学的快速发展,个体间的基因序列差异与ADR之间的相关性不断被证实,但是缺乏全面的归纳和总结。基于遗传药理学和药物基因组学知识库(PharmGKB)和临床药物遗传学实施联盟(CPIC)、美国食品和药品管理局(FDA)等权威组织发布的药物基因组学相关指南,综述近年来高证据等级的基因多态性在预测和避免ADR中的最新进展和重要意义,以期为基因导向的个体化给药提供参考。
|
| 关 键 词： | 药物相关基因 基因多态性 药物不良反应 个体化给药 |
Correlation between Gene Polymorphism and Risk of Adverse Drug Reaction and Its Clinical Evidence |
| |
| LI Yujiao,CHU Yanan,HUANG Xiaohui,ZHANG Jieyu,ZHOU Guohua.Correlation between Gene Polymorphism and Risk of Adverse Drug Reaction and Its Clinical Evidence[J].Progress in Pharmaceutical Sciences,2021(2):100-111. |
| |
| Authors: | LI Yujiao CHU Yanan HUANG Xiaohui ZHANG Jieyu ZHOU Guohua |
| |
| Affiliation: | (Department of Clinical Pharmacy,General Hospital of Eastern Theater Command,People’s Liberation Army,Nanjing 210002,China) |
| |
| Abstract: | Adverse drug reaction(ADR),a big issue in clinical medication,greatly affects drug efficacy and seriously threatens the safety of patients.With the rapid development of pharmacogenomics,the clinical correlation between gene polymorphism and ADR has been continuously confirmed,but there is a lack of comprehensive review.Based on Pharmacogenomics Knowledgebase(PharmGKB),pharmacogenomics-related guidelines published by the Clinical Pharmacogenetics Implementation Consortium(CPIC),the US Food and Drug Administration(FDA)and other authoritative organizations,this paper summarizes the significance and recent advances of gene polymorphism with high level of evidence in predicting and avoiding ADR,in order to provide reference for gene-directed individualized medication. |
| |
| Keywords: | drug-related gene gene polymorphism adverse effect individualized medication |
| 本文献已被 维普 等数据库收录！ |
|
