有氧运动合用人参皂苷对饮食性高脂血症小鼠脂质代谢的影响

目的；研究有氧运动及其合用人参茎叶皂苷对饮食性高脂血症小鼠脂质代谢的影响。方法；通过喂养高胆固醇饲料２０天建立高脂血症模型，以无负重游泳作为有氧运动方式，观察有氧运动及其合用Ｇｉｎ时对高脂状态下小鼠的影响。结果：（１）高胆固醇饲料喂养２０天，小鼠血清ＴＣ，ＭＤＡ升高，ＨＤＬ－ｃ和ＳＯＤ降低，高脂血症模型民功，肝重量增加，有脂肪肝出现，胸腺重量减轻。（２）有氧运动降低ＴＣ，升高ＭＤＡ和ＨＤＬ－ｃ，肝

Effect of aerobic exercise and ginsenosides on lipid metabolism in diet-induced hyperlipidemia mice.

AIM: To study the effect of aerobic exercise and its combination with Gin (ginsenosides from stems and leaves of ginseng) on lipid metabolism in diet-induced hyperlipidemia mice. METHODS: The mouse hyperlipidemia model was set up by feeding high cholesterol diet. Unloaded swimming was designed to be a manner of aerobic exercise. The effects of aerobic exercise and its combination with Gin on total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-c) in serum, malondialdehyde (MDA), and superoxide dismutase (SOD) in liver tissue were measured; the thymus and liver were weighed. RESULTS: (1) The mouse hyperlipidemia model was set up successfully: TC and MDA increased (P < 0.05) but HDL-c and SOD decreased (P < 0.05); the liver weight increased and the thymus weight reduced; fatty liver was found; (2) aerobic exercise reduced TC but increased MDA and HDL-c in cholesterol-rich diet mice; the liver weight did not reduce, and fatty liver did not clear up; and (3) when aerobic exercise combined with Gin, TC and TG decreased markedly (P < 0.01), and MDA also decreased (P < 0.05); SOD and HDL-c increased markedly (P < 0.01); the thymus weight increased and the liver weight decreased to normal level; fatty liver cleared up. CONCLUSION: Aerobic exercise could lower serum lipid to some extent but could not satisfactorily regulate lipid metabolism. When combined with Gin, aerobic exercise could better lower serum lipid, regulate lipid metabolism, promote antioxidation, and enhance immune activity.