阿托伐他汀强化治疗对急性冠脉综合征患者氧化应激的影响

目的探讨阿托伐他汀强化治疗对急性冠脉综合征患者氧化应激的影响及可能机制。方法 62例ACS患者和25例健康体检者入选本研究,其中38例ACS患者入选阿托伐他汀强化治疗组(80 mg/12h内),另外25例ACS患者入选阿托伐他汀常规治疗组(40 mg/d)。所有入选者入院后及即刻与第2d检测血浆oxLDL、SOD与MDA水平。结果阿托伐他汀80 mg强化治疗能下调oxLDL水平,与常规治疗组有显著差异(P=0.02);强化治疗组患者血浆SOD水平显著高于常规治疗组,P<0.05;80 mg阿托伐他汀强化治疗还能显著降低血浆MDA浓度。结论 80 mg阿托伐他汀强化治疗较40mg常规治疗具有更强的抗氧化应激作用。

The effects of short-term high-dose atorvastatin on oxidative stress in patients with acute coronary syndromes

Objective To investigate the possible protective mechanisms of short-term high-dose atorvastatin pretreatment and its effects on oxidative stress in patients with acute coronary syndromes(ACS).Methods 62 ACS patients were enrolled in our study and randomly divided into atorvastatin reload group(80 mg within 12 hours) and conventional atorvastatin group(40 mg before intervention),25 healthy volunteers were enrolled as control group.The serum levels of oxidized low density lipoprotein(oxLDL) and superoxide dismutase(SOD),as well as malondialdehyde(MDA) of each patient were observed immediately and in the second day of hospitalization.Results Compared with conventional atorvastatin group,80 mg high-dose treatment could downregulate the expression of oxLDL(P=0.02).The concentration of SOD in 80 mg group was significantly higher than that of conventional group P<0.05,while the serum MDA levels was lower in 80 mg atorvastatin reload group.Conclusion 80 mg atorvastatin high-dose treatment could more effectively antagonize oxidative stress in ACS patients.