| PBTEOLA共聚酯体内外降解及组织相容性 |
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| 引用本文： | 崔苏萍,王英磊,陈义旺,汪泱,谢安,娄远蕾,朱祥军.PBTEOLA共聚酯体内外降解及组织相容性[J].江西医药,2009,44(2):109-113. |
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| 作者姓名： | 崔苏萍 王英磊 陈义旺 汪泱 谢安 娄远蕾 朱祥军 |
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| 作者单位： | 1. 南昌大学第一附属医院,南昌,330006
2. 南昌大学材料学院,南昌,330031 |
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| 摘 要： | 目的探讨国产生物降解泌尿系支架材料（对苯二甲酸丁二醇酯-co-聚乙二醇-co-低聚乳酸）三元共聚酯（PBTEOLA）的组织相容性及体内、体外降解特性。方法将PBTEOLA试件埋植在SD大鼠脊柱两侧皮下组织内或浸泡于磷酸盐缓冲液中，分别于2、4、6、8、10、12、14及16周取出．通过组织病理学切片研究材料周围组织反应，利用扫描啦谴检夏材料的表面征象，准确称重以检测材料降解前后的重量。以了解PBTEOLA在体内、体外的降解情况和组织相容性。结果PBTEOLA材料在16周内可降解为细小颗粒．材料的体内、体外降解趋势相同，体内降解速度略快于体外降解。埋植材料周围皮下组织无脓肿形成和组织坏死发生，局部组织反也为轻微的炎症反应。结论PBTEOLA材料组织相容性良好，降解时间适宜，适用于制备泌尿系支架，可进一步研究开发。
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| 关 键 词： | 可降解生物材料 组织相容性 泌尿道 支架 |
Biocompatibility and biodegradation characteristics of poly(PBTEOLA)in vivo and in vitro |
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| CUI Supping,WANG Yinglei,CHEN Yiwang,et al..Biocompatibility and biodegradation characteristics of poly(PBTEOLA)in vivo and in vitro[J].Jiangxi Medical Journal,2009,44(2):109-113. |
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| Authors: | CUI Supping WANG Yinglei CHEN Yiwang |
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| Affiliation: | CUI Supping,WANG Yinglei,CHEN Yiwang,et al.Department of Urology,the First Affiliated Hospital of NanChang University,NanChang,330006,China |
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| Abstract: | Objective To study the histocompatibility and biodegradation characteristics of poly(1,4-butylene terephthalate-co-ethylene oxide-co-DL-lactide)(PBTEOLA),a kind of biodegradable material,used for uro-logical stent in vivo and in vitro.Methods Pellets made from PBTEOLA were implanted in the dorsal subcuta-neous tissue of SD rats or dipped into phosphate buffer.Tissue blocks surrounding the biomateriaIs and the PB-TEOLA pellets were took out after 2,4,6,8,10,12,14 and 16 weeks,respectively.Histological study ... |
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| Keywords: | Biodegradable material Histocompatibility Urinary tract Stents |
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