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| 99mTc-半乳糖基明胶的制备及其作为肝显像剂的可能性 | |
| 引用本文： | 宋志平,庞其捷,李铜铃,管昌田,邓志宏,毛洁.99mTc-半乳糖基明胶的制备及其作为肝显像剂的可能性[J].华西药学杂志,1999,14(3):154-156. |
| 作者姓名： | 宋志平 庞其捷 李铜铃 管昌田 邓志宏 毛洁 |
| 作者单位： | 1. 华西医科大学制药厂,成都,610041 2. 华西医科大学药学院,成都,610041 3. 华西医科大学附一院核医学科,成都,610041 |
| 摘 要： | 报道了以半乳糖为原料制得２－亚氨基－２－甲氧乙基－１－硫代－β－Ｄ－半乳吡喃糖苷，再与药用明胶偶联制得半乳糖基明胶（ｇａｌａｃｔｏｓｙｌｇｅｌａｔｉｎ，ＧＧ）的方法，并用９９ｍＴｃ标记后进行了动物肝显像及体内分布试验，结果表明，９９ｍＴｃ－ＧＧ主要集中于肝脏，肝显像清晰，有可能作为一种新的肝受体显像剂。 |
| 关 键 词： | 无唾液酸糖蛋白受体 半乳糖基新糖白蛋白 半乳糖基明胶 糖密度 放射性核素显像 肝受体显像 |
PREPARATION OF 99mTC-GALACTOSYL GELATIN AND ITS PROBA-BILITY TO BE USED AS A HEPATIC RADIOGRAPHY REAGENT |
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| Song Zhiping,Pang Qijie,Li Tongling,Guan Changtian,Deng Zhihong,Mao Jie.PREPARATION OF 99mTC-GALACTOSYL GELATIN AND ITS PROBA-BILITY TO BE USED AS A HEPATIC RADIOGRAPHY REAGENT[J].West China Journal of Pharmaceutical Sciences,1999,14(3):154-156. | |
| Authors: | Song Zhiping Pang Qijie Li Tongling Guan Changtian Deng Zhihong Mao Jie |
| Abstract: | Galactosyl gelatin (GG) was synthesized by the covalent coupling of a carbohydrate bifunctional reagent, 2imino2methoxyethyl1thiogalactose, to medical gelatin. Animal tests of radiograph in rabbit and the tissue radioactivity distribution in mice with,7 99m Tc labeled GG showed that 99mTcGG can be concentrated specifically in liver, and is possible to be used as a hepatic radiography reagent. |
| Keywords: | Asialoglycoprotein receptorGalactosylneoglycoalbuminGalactosyl GelatinCarbohydrate densityRadiographyHepatic receptor radiography |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
