2013年某中医院ICU抗菌药物使用情况与细菌耐药性的相关性研究

目的：调查某中医院ICU抗菌药物的应用及细菌学情况，分析细菌耐药性，对抗菌药物使用情况进行评价。方法：利用Excel对ICU病房2003年1～12月抗菌药物的使用情况、细菌检查结果及其耐药性进行回顾性分析。结果：各类抗菌药物使用按DDDs排序，前三位分别为头孢菌素类（793.3）、碳青霉烯类（687.8）、四环素类（251.0）；按使用总量排序，前三位分别为美罗培南（1353.0g）、头孢哌酮舒巴坦（883.0g）、哌拉西林他唑巴坦（877.5g）。2013年ICU送检标本检出的146株细菌中，G-菌占82.2%，共120株，其中鲍曼不动杆菌64株；真菌占11.6%，共17株，其中白假丝酵母菌11株；G+菌占6.2%，共9株。结论：ICU抗菌药物使用特点符合检出细菌分布情况，细菌耐药性与抗菌药物的DDDs呈正相关性。

Analysis of Use of Antibacterial Drugs and Bacterial Resistance in ICU of Hospital of TCM in 2013

Objective:Investigate applications of antimicrobial agents and bacteriological conditions in ICU of Hospital of TCM,analyze bacterial resistance and evaluate the reasonableness of the use of antimicrobial drugs. Method: Retrospective analyze the use of antimicrobial drugs, the results of bacteria test and its resistance in 2013 by Excel. Results: Sort by DDDs, the top three were cephalosporins(793.3), carbapenems(687.8), tetracyclines(251.0);Sorted by the total amount of use, the top three were meropenem (1353.0g), cefoperazone sulbactam (883.0g), piperacillin tazobactam (877.5g). In 146 cases of detected bacteria, G-accounted for 82.2%, a total of 120, including Acinetobacter baumannii 64; Fungi accounted for 11.6%, a total of 17, including Acinetobacter baumannii 11;G+accounted for 6.2%, a total of 9.Conclusion: Antimicrobial drug use characteristics consistent with the distribution of the detection of bacteria in ICU, bacterial resistance and antimicrobial drugs DDDs were positively correlated.