中药注射剂致儿童药源性疾病的流行病学分析

目的 了解中药注射剂所致儿童药源性疾病的流行病学特点，为减少和避免药源性疾病的发生提供参考依据。方法 通过计算机检索CNKI中国期刊全文数据库，对1994～2004年国内期刊上公开报道的202例中药注射剂引起的儿童药源性疾病进行统计分析。结果 202例中药注射剂引起的儿童DID中，男性多于女性，各年龄阶段呈倒梯形分布，新生儿期发生率最低，而学龄期儿童最高；清热解毒类中药注射剂是致儿童DID的主要药物；变态反应的发生率最高，过敏性休克是致死的主要原因。结论 中药注射剂所致的儿童药源性疾病，多数情况下病情较为轻微，治疗预后良好，但临床上应注意其特点合理使用，以避免严重后果。

Epidemiological analysis on drug-induced diseases in children caused by traditional chinese medicine injections

Objective To help reduce and avoid drug-induced diseases(DIDs)by analyzing the epidemiological feature of DIDs in children caused by Traditional Chinese Medicine Injections(TCMJs).Methods Statistically analyzing the DIDs of 202 cases reported publicly between 1994 and 2004 by searching in the database of the website of CNKI.Results Of the 202 cases,males are found more than females,and the incidence rate in newborn babies is the lowest with that is the highest in children of school age.Heat-clearing and detoxicating TCMJs are the main kind drugs to cause DIDs in children.The incidence rate of allergic reaction is the highest,and allergic shock is the main reason for death.Conclusion In general,the DIDs caused by TCMJs are slight and can be cured,but to avoid severe events,rational use of TCMJs should be noted.