Lycopene and resveratrol ameliorate zinc oxide nanoparticles-induced oxidative stress in Nile tilapia,Oreochromis niloticus |
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| Affiliation: | 1. Physiology and Pharmacology Department, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil;2. Chemistry Department, Federal University of Santa Maria, 97105-900, Santa Maria, RS, Brazil;1. Department of Biology and Marine Biology, University of North Carolina Wilmington, 601 S. College Rd., Wilmington, NC 28403, USA;2. Division of Natural Sciences and Engineering, University of South Carolina Upstate, 800 University Way, Spartanburg, SC 29303, USA;3. Center for Marine Science, University of North Carolina Wilmington, 601 S. College Rd., Wilmington, NC 28403, USA;1. University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Vodňany, Czech Republic;2. Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacký University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic;3. Helmholtz-Centre for Environmental Research—UFZ, Department of Molecular Systems Biology, Leipzig, Germany;4. University of Leipzig, Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig, Germany;5. Aalborg University, Department of Chemistry and Bioscience, 9220 Aalborg, Denmark |
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| Abstract: | Industrial products contained nano-zinc oxide (ZnONP) can gain access to the aquaculture environment causing hazardous effects on the living biota. Therefore, this work was planned to examine the ameliorative effects of dietary supplementation of lycopene (LYC) and/or resveratrol (RES) against ZnONP toxicity in Nile tilapia. Five groups with 20 fish each were used; Control, received tap water only; ZnONP group, was intoxicated with ZnONP (50 mg/L); ZnONP-LYC group, was exposed to ZnONP and LYC (500 mg/ kg of the diet); ZnONP-RES group, was exposed to ZnONP and RES (50 mg/kg of the diet); ZnONP-LYC-RES group, was exposed to ZnONP and a combination of LYC and RES. The experiment was continued for 30 days. Fish blood and tissues were then assembled for determination of liver and kidney function and oxidative stress status in liver, kidney, and gills tissue. Results revealed a considerable elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), cholesterol, urea, and creatinine with a noticeable lowering of total proteins and albumin serum levels in response to ZnONP intoxication. In addition, there were significant increase in malondialdehyde (MDA) and reduction in the reduced-glutathione (GSH) levels and superoxide dismutase (SOD) and catalase (CAT) activities. However, treatment with LYC and/or RES ameliorated the ZnONP-inflicted oxidative stress which possibly attributed to their beneficial antioxidant activities. |
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| Keywords: | Zinc oxide nanoparticles Lycopene Resveratrol Antioxidants Oxidative stress |
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