取宫内节育器后继发不孕妇女血清免疫学检查结查分析

目的:探讨取宫内节育器(IUD)后继发不孕妇女血清中抗精子抗体(AsAb)、抗子宫内膜抗体(EMAb)、抗卵巢抗体(AoAb)和抗心磷脂抗体(ACA)的发生率及其作用,为临床病因分析和治疗提供依据。方法:采用酶联免疫吸附法(ELISA)对96例取IUD后继发不孕妇女、270例原发不孕妇女和50例正常生育未置IUD妇女(对照组)血清AsAb、EMAb、AoAb和ACA进行检测,并对检测结果进行统计分析。结果:取IUD后继发不孕妇女血清AsAb阳性32例(33.3%),EMAb阳性26例(27.1%),AoAb阳性21例(21.9%),ACA阳性25例(26.0%)其阳性率均显著高于对照组(P<0.01),同时AsAb和EMAb阳性率分别显著高于原发不孕组(P<0.01)。结论:取IUD后继发不孕妇女血清中AsAb、EMAb、AoAb和ACA阳性率显著升高,这可能是取IUD后继发不孕的一个重要原因。对取IUD后不孕妇女进行血清AsAb、EMAb、AoAb和ACA的检测具有一定意义。

Analysis of serum immunological tests in secondary infertility female after extracting intrauterine contraceptive device

Objective:To study the incidence and effect of serum AsAb?EMAb?AoAb and ACA in secondary infertility females after extracting Intrauterine contraceptive Device(IUD),in order to offer basis for clinical pathogeny analysis and clinical therapy.Methods:The ELISA was used to detect serum AsAb,EMAb,AoAb and ACA in 96 secondary infertility females after extracting IUD,270 original infertiligy females and 50 normal fertility females without taking IUD(contrasting group) and a statistical analysis to the test result was performed.Results:The positive patients of AsAb,EMAb,AoAb and ACA were 32 case(33.3%),26 case(27.1%),21 case(21.9%),25 case(26.0%) respectively,the positive rates of them were all significantly higher than those of the contrasting group(P<0.01),and the positive rates of AsAb,EMAb were significantly higher than those of the original infertility group respectively(P<0.01).Conclusion:The positive rates of serum AsAb,EMAb,ACA and AoAb in secondary infertility females after extracting IUD are increased significantly and it may be an important factor for the secondary infertility.So it may have definite significance to detect serum AsAb,EMAb,AoAb and ACA in secondary infertility females after extracting IUD.