文拉法辛联合解郁汤治疗难治性抑郁症疗效分析

目的 了解文拉法辛联合解郁汤治疗难治性抑郁症( treatment-resistant depression,TRD)的疗效和不良反应.方法 将76例患者随机分为研究组和对照组,研究组采用文拉法辛联合解郁汤治疗,对照组采用文拉法辛治疗.在治疗前及治疗第2、4、6周进行汉密尔顿抑郁量表(HAMD评定,按HAMD减分率判定疗效,药物不良反应采用不良反应量表(TESS)评定.结果 研究组有效率79.41％,对照组有效率56.25％,两组比较差异有统计学意义(x2=4.08,P＜0.05).在治疗后第2周起,两组间HAMD评分有统计学差异(t=2.21,P＜0.05)、研究组不良反应发生率低于对照组.结论 文拉法辛联合解郁汤治疗TRD疗效优于单独使用文拉法辛,起效更快,不良反应轻.

Effective analysis of venlafaxin combined Jeiyu Decoction in treatment of refractory depression

Objective To explore the effect and adverse reactions of venlafaxin combined Jeiyu Decoction in the treatment of refractory depression.Methods 76 patients were randomly assigned to the research group and the control group.Venlafaxin combined Jeiyu Decoction were used in the research group.But the control group only used venlafaxin.The two groups were assessed with HAMD before treatment and at 2,4,6 weeks of the treatment.The effects were evaluated by the score reducing rate of HAMD.Adverse reactions were assessed by the Treatment Emergent Symptom Scale(TESS).Results The effective rate was 79.41% in the research group and 56.25% in the control group,showing statistical difference between the two groups(χ2=4.08,P<0.05).After two weeks,there was statistical difference in the scores of HAMD between the two groups(t=2.21,P<0.05).The rate of adverse reactions in the research group was lower than that in the control group.Conclusion The effects of venlafaxin combined Jieyu Decoction is superior to single venlafaxin in the treatment of refractory depression with more rapid efficacy,and milder adverse reactions.