| 肺靶向利福平聚乳酸微球的体外释药性能 |
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| 引用本文： | 张万国,蒋雪涛.肺靶向利福平聚乳酸微球的体外释药性能[J].中国医院药学杂志,1997,17(10):442-444. |
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| 作者姓名： | 张万国 蒋雪涛 |
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| 作者单位： | 上海第二军医大学药学院(张万国)，上海长海医院药剂科(蒋雪涛) |
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| 摘 要： | 本文以０．９％氯化钠的水溶液为释放介质，对利福平聚乳酸微球的体外释药进行了研究。结果表明，微球在最初１０ｍｉｎ有突释效应，此后累积释药量与时间平方根之间呈线性关系。分别考察了微球大小、聚乳酸浓度、微球含药量、制备微球时在甘油中的分散时间和在明胶水溶液中的扩散时间等因素对微球释药性能的影响。
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| 关 键 词： | 利福平，聚乳酸，微球，体外释药试验 |
Study on rifampicin polylactic acid microspheres for lung targesting in vitro release properties |
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| Zhang Wanguo,Jiang Xuetao.Study on rifampicin polylactic acid microspheres for lung targesting in vitro release properties[J].Chinese Journal of Hospital Pharmacy,1997,17(10):442-444. |
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| Authors: | Zhang Wanguo Jiang Xuetao |
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| Abstract: | In vitro dissolution tests of rifampicin polylactic acid microspheres were carried out, using 0.9% NaCl aquaous solution as dissolution medium. A linearship between cumulative release percent and scuare root time could be seen except that there exist a burst effect within the first 10 min. Various factors, such as particle size, PLA concentration, drug content, dispersing time in glycerin and diffusion time in gelatin aqueous solution during preparation, that could affect the release properties of PLA microspheres were studied in detail. |
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| Keywords: | rifampicin polylactic acid microspheres in vitro dissolution tests |
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