| 复方磺胺米隆凝胶的制备及质量控制 |
| |
| 引用本文： | 吴明钗,谢兵,胡瑞颖.复方磺胺米隆凝胶的制备及质量控制[J].中国医院药学杂志,2006,26(12):1506-1508. |
| |
| 作者姓名： | 吴明钗 谢兵 胡瑞颖 |
| |
| 作者单位： | 温州医学院附属第三医院,浙江,瑞安,325200 |
| |
| 摘 要： | 目的:建立复方磺胺米隆凝胶制备及质量控制方法。方法:以醋酸磺胺米隆和盐酸达克罗宁为主药,以羧甲基纤维钠和甘油为基质,制备水溶性凝胶,以紫外分光光度法测定含量。结果:凝胶pH6.0~7.0,其他各项检查均符合有关规定,醋酸磺胺米隆平均回收率为99.49%,RSD为0.84%;盐酸达克罗宁回收率为100.2%,RSD为0.84%。结论:该制剂制备工艺简单,性质稳定,质量可控。
|
| 关 键 词： | 醋酸磺胺米隆 盐酸达克罗宁 凝胶剂 |
| 文章编号： | 1001-5213(2006)12-1506-03 |
| 收稿时间： | 2006-03-28 |
| 修稿时间： | 2006年3月28日 |
Preparation and quality control of compound mafenide gel |
| |
| WU Ming-chai,XIE Bing,HU Rui-ying.Preparation and quality control of compound mafenide gel[J].Chinese Journal of Hospital Pharmacy,2006,26(12):1506-1508. |
| |
| Authors: | WU Ming-chai XIE Bing HU Rui-ying |
| |
| Abstract: | OBJECTIVE To establish a method for preparation and quality control of the compound mafenide gel.METHODS The gel was prepared by taking mafenide acetate and dyclonine hydrochloride as main components,carboxymethylcellulose sodium and glycerol as base material.The contents were detrmened whith UV spectrophotometry.RESULTS The gel pH value was 6.0-7.0,other tests accord with the requirements of gel.The average recovery of mafenide acetate was 99.49%,RSD=0.97%;and the recoaery of dyclonine hydrochloride was 100.2%,RSD=0.84%.CONCLUSION The preparation of the gel is simple.The gel is stable and its quality can be controlled. |
| |
| Keywords: | mafenide acetate dyclonine hydrochloride gel |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
