51例中药注射剂不良反应／事件分析

目的分析中药注射剂不良反应／事件的发生情况及相关因素，为临床合理用药提供参考。方法对我院2006～2007年上报的51例中药注射剂不良反应／事件报告表进行回顾性分析。结果本组不良反应／事件以皮肤及其附件损害和药物热为主，共36例次，占52.9％涉及13个注射剂品种，其中痰热清、双黄连、喜炎平3种注射剂共诱发27例不良反应／事件，占52.9％。结论应提倡中药口吸取途径给药，慎用中药注射剂，加强对中药注射剂不良反应/事件的监测和相关研究，提高临床用药的安全性。

Analysis of 51 Adverse Drug Reactions/Events Induced by Traditional Chinese Medicine Injections

Objective The condition and related factors of adverse drug reactions/events induced by traditional Chinese medicine injections are analyzed to provide references for clinical use. Methods 51 adverse drug reactions/events induced by traditional Chinese medicine injections reported from 2006 to 2007 in the hospital have been analyzed retrospectively. Results The main clinical symptoms of 36 cases which account for 52.9% of 51 cases are skin and appendages disorders and drug fever. 51 cases involve 13 injections. 27 cases caused by Tanreqing injection, Shuanghuanlian injection and Xiyanping injection account for 52.9% of all cases. Conclusion It is advocated that the traditional Chinese medicine should be taken orally and the use of traditional Chinese medicine injections must be careful. The monitoring of adverse drug reactions/events induced by traditional Chinese medicine injections and related study should be strengthened to improve the clinical safety.