海洋来源的微管去稳定剂抗肿瘤药物研究进展

摘要：微管是细胞骨架重要组成成分，是筛选抗肿瘤药物的重要靶标。海洋生态系统的极端环境使海洋生物具备产生独特 化学结构和生理活性天然产物的能力，为新药发现提供了物质基础。本文主要综述了1972-2021年从海洋生物中分离鉴定的成 药性较好的微管去稳定剂抗肿瘤药物的研究进展，总结了活性化合物来源、构效关系，临床研究进展，化学全合成及衍生物的 研究情况等，以期为医药工作者提供新的研究思路，推进靶向微管海洋抗肿瘤药物的发展。

Advances in antitumor drugs of microtubule destabilizers from marine-derived organisms

Abstract Microtubules are important components of the cytoskeleton and regarded as an important target for screening antitumor drugs. The extreme environment of the marine ecosystem enables marine organisms to produce unique chemical structures and physiologically active natural products, providing a material basis for new drug discovery. This paper mainly reviews the research progress in the isolation and identification of antitumor microtubule destabilizer with great medicinal properties from marine organisms from 1972 to 2021, and summarizes the source of active compounds, structure-activity relationship, clinical research progress, and the research status of chemical synthesis and derivatives, it is expected to provide new research ideas for medical researchers and promote the development of marine anti-tumor drugs targeting