| 阿柔比星A聚乳酸毫微粒冻干针剂小鼠体内分布研究 |
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| 引用本文： | 何林,蒋学华.阿柔比星A聚乳酸毫微粒冻干针剂小鼠体内分布研究[J].中国抗生素杂志,2000,25(3):214-217. |
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| 作者姓名： | 何林 蒋学华 |
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| 作者单位： | 1. 四川省人民医院药剂科,成都,610072
2. 华西医科大学药学院,成都,610041 |
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| 基金项目： | 国家自然科学基金!资助项目 (合同号 39570 842 )，国家医药技术创新博士项目! (合同号 95- B- 0 9) |
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| 摘 要： | 对阿柔比星Ａ冻干针剂与阿柔比星Ａ聚乳酸毫微粒冻干针剂给予小鼠尾静脉注射后体内分布比较，采用ＨＯＬＣ法分别测定小鼠给药后血液及主要脏器中ＡＣＲＢ０Ａ浓度。结果阿柔比星Ａ聚乳酸毫微粒在小鼠肝脏中的浓度高于对照品浓度。
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| 关 键 词： | 阿柔比星A 聚乳酸毫微粒 体内分布 冻干针剂 |
Study on the distribution of aclarubicin A poly lactide nanoparticle lyophilization in mice |
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| He Lin,Jiang Xuehua.Study on the distribution of aclarubicin A poly lactide nanoparticle lyophilization in mice[J].Chinese Journal of Antibiotics,2000,25(3):214-217. |
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| Authors: | He Lin Jiang Xuehua |
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| Abstract: | Objective: Comparing the distribution of aclarubicin A lyophilization and aclarubicin A poly lactide nanoparticle (ACRB A PLA NP) lyophilization in mice. Method: HPLC is selected to determine the concentration of aclarubicin A in plasma and in main organisms. Results: The concentratin of ACRB A PLA NP in liver is higher than that of the reference. Conclusion: ACRB A can be significantly concentrated in liver after prepared in nanoparticle. |
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| Keywords: | Aclarubicin A Poly lactide Nanoparticle In vivo distribution |
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