| 头孢呋辛钠合成工艺的改进 |
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| 引用本文： | 游莉,刘家健,刘敦茀,李江红.头孢呋辛钠合成工艺的改进[J].中国抗生素杂志,2004,29(10):585-587. |
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| 作者姓名： | 游莉 刘家健 刘敦茀 李江红 |
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| 作者单位： | 中国医药集团四川抗菌素工业研究所,成都,610051 |
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| 摘 要： | 本文报道头孢呋辛钠的工艺改进。7-ACA的C7-NH2位用活性酯法与侧链顺式]-2-2-呋喃基]-2-甲氧亚氨基]乙酸缩合后,C3位脱乙酰基成3-去氨甲酰基-头孢呋辛酸(DCCF)。再与氯磺酸异氰酸酯反应得头孢呋辛酸,成盐后得目标化合物。以7-ACA为基准,合成总收率为63.0%.
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| 关 键 词： | 头孢呋辛钠 头孢呋辛酸 7-ACA 合成 |
| 文章编号： | 1001-8689(2004)10-0585-03 |
| 修稿时间： | 2004年5月10日 |
Process development of cefuroxime sodium |
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| You Li,Liu Jia jian,Liu Dun fu and Li Jiang hong.Process development of cefuroxime sodium[J].Chinese Journal of Antibiotics,2004,29(10):585-587. |
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| Authors: | You Li Liu Jia jian Liu Dun fu and Li Jiang hong |
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| Abstract: | This paper describes the process development of cefuroxime sodium, 7 amino cephalosporin acid by condensing with the side chain compound (Z] 2(2 furyl) 2 (methoxyimino) acetic acid) with the active ester on C 7 position, and then deacetylated on C 3 position to obtain 3 decarbamoyl cefuroxime (DCCF). Subsequently, DCCF reacted with chlorosulfonic isocyante to give cefuroxime acid. Then the acid was con verted to cefuroxime sodium. The total yield of the process based on 7 ACA was 63%. |
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| Keywords: | Cefuroxime acid Cefuroxime sodium 7-ACA Process |
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