| 弯孢马利亚霉SIIA-F12361产生的新代谢产物研究 |
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| 引用本文： | 王辂,郭义东,褚以文.弯孢马利亚霉SIIA-F12361产生的新代谢产物研究[J].中国抗生素杂志,2011,36(3). |
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| 作者姓名： | 王辂 郭义东 褚以文 |
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| 作者单位： | 抗生素研究与再评价四川省重点实验室,中国医药集团总公司四川抗菌素工业研究所,成都,610052 |
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| 基金项目： | 科技基础条件平台项目，天然药物及仿生药物国家重点实验室(北京大学)开放基金，抗生素研究与再评价四川省重点实验室开放基金 |
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| 摘 要： | 目的:对海洋生境来源菌株SIIA-F12361进行分类学鉴定以及次级代谢产物的化学研究.方法:采用形态学与18S rDNA序列分析对菌株进行分类学鉴定.通过硅胶柱层析、LH-20分子筛层析和反相制备HPLC诸方法,对新化合物进行分离纯化,并根据高分辨质谱、紫外、红外光谱和核磁共振数据对化合物SIIA-C12361进行结构鉴定.结果:鉴定菌株SIIA-F12361为弯孢马利亚霉,其产生的新次级代谢产物属于倍半萜烯内酯类化合物.结论:弯孢马利亚霉SIIA-F12361产生一新倍半萜烯内酯化合物.
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| 关 键 词： | 弯孢马利亚霉 倍半萜烯内酯 分离纯化 结构解析 |
A novel secondary metabolite from Mariannaea campospora SIIA-F12361 |
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| Wang Lu,Guo Yi-dong,Chu Yi-wen.A novel secondary metabolite from Mariannaea campospora SIIA-F12361[J].Chinese Journal of Antibiotics,2011,36(3). |
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| Authors: | Wang Lu Guo Yi-dong Chu Yi-wen |
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| Affiliation: | Wang Lu,Guo Yi-dong and Chu Yi-wen(Antibiotics Research and Re-profiling Key Lab of Sichuan Province,Sichuan Industrial Institute of Antibiotics,China National Pharmaceutical Group Corporation,Chengdu 610052) |
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| Abstract: | Objective To investigate the taxonomy of a fungal strain SIIA-F12361 isolated from marine environment,as well as its secondary metabolites.Methods The strain SIIA-F12361 was identified by morphology and 18S rDNA sequence analysis.The compound SIIA-C12361 was isolated by using silica gel column chromatography,LH-20 chromatography and preparative HPLC.The planner structure of SIIA-C12361 was determined through extensive analysis of MS,UV,IR and various NMR spectroscopic data.Results The isolate of SIIA-F12361... |
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| Keywords: | Mariannaea campospora Sesquiterpene lactone Isolation and purification Structure elucidation |
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