| 抗病毒药物耐药及耐药机制研究进展 |
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| 引用本文： | 陶佩珍.抗病毒药物耐药及耐药机制研究进展[J].中国抗生素杂志,2006,31(2):72-79,106. |
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| 作者姓名： | 陶佩珍 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,医药生物技术研究所,北京,100050 |
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| 摘 要： | 目前临床应用的抗病毒药物达40多种，为病毒引起的疾病的治疗发挥了重大作用。与临床其他抗感染药物一样，抗病毒药物长期应用易产生耐药性．降低疗效，成为临床治疗及新药开发的重要问题。本文就抗艾滋病毒药物、抗乙型肝炎病毒药物、抗流感病毒药物及抗疱疹病毒药物耐药性及耐药机制研究进行综述。
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| 关 键 词： | 抗病毒药 耐药性 耐药机制 |
| 文章编号： | 1001-8689（2006）02-0072-08 |
Advances in antiviral drug resistance and resistance mechanisms |
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| Tao Pei-zhen.Advances in antiviral drug resistance and resistance mechanisms[J].Chinese Journal of Antibiotics,2006,31(2):72-79,106. |
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| Authors: | Tao Pei-zhen |
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| Affiliation: | Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Seienees~ Beijing 100050 |
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| Abstract: | There are more than 40 anti-virus drugs in the clinical use, which have played very important role in the treatment of viral diseases. I.ike other kind of anti-infection drugs, anti-virus drugs can also induce resistance in long-time use that results the reducing of therapeutic efficacy and becoming a very tough problem in the clinical treatment and the development of new drugs. This paper briefly reviewed the recent advances in resistance and resistance mechanisms of anti-HIV drugs, anti HBV drugs, anti-influenza drugs and anti-HSV drugs. |
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| Keywords: | Anti-virus drugs Resistancel Resistance mechanisms |
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