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Metabolism of chloral hydrate in the anoxic perfused liver |
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| Authors: | Toshihiro Kawamoto Tatsuya Hobara Tatsuya Aoki Haruo Kobayashi Susumu Iwamoto Tsunemi Sakai Takehito Takano Yoshifumi Miyazaki Akihisa Imamura Keiki Ogino |
| Affiliation: | 1 Department of Public Health, Yamaguchi University School of Medicine, 1144, Kogushi, Ube 755, Japan 2 Department of Public Health, Faculty of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113, Japan 3 Department of Hygiene and Environmental Health, Faculty of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113, Japan 4 Department of Pharmaceutical Science, Yamaguchi University School of Medicine, 1144, Kogushi, Ube 755, Japan 5 1st Department of Internal Medicine, Yamaguchi University School of Medicine, 1144, Kogushi, Ube 755, Japan |
| Abstract: | The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion. |
| Keywords: | Chloral hydrate: Trichloroethanol Trichloroacetic acid Anoxia Liver Perfusion Drug metabolism |
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