| 猪肺表面活性物质冻干粉的激光散射粒度分析 |
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| 引用本文： | 叶小敏,田颂九,李慧义,张启明.猪肺表面活性物质冻干粉的激光散射粒度分析[J].药物分析杂志,2007,27(6):863-866. |
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| 作者姓名： | 叶小敏 田颂九 李慧义 张启明 |
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| 作者单位： | 武汉市药品检验所，中国药品生物制品检定所 |
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| 基金项目： | 致谢：感谢中国药品生物制品检定所邹文博先生及广西壮族自治区药品检验所朱建萍女士对本文提供帮助. |
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| 摘 要： | 目的:建立猪肺表面活性物质冻干粉的粒度分析方法。方法:分别测定了以0.9%氯化钠溶液及蒸馏水为分散介质时样品混悬液的粒度分布情况,同时辅以 Zeta 电位测定以考察样品混悬液的稳定性。结果:以蒸馏水为分散介质时样品的分散效果较好。结论:本方法可快速、简单、准确地测定猪肺表面活性物质冻干粉混悬液的粒度分布。
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| 关 键 词： | 猪肺表面活性物质冻干粉 激光散射粒度分析 Zeta 电位 |
| 文章编号： | 0254-1793（2007）06-0863-04 |
| 修稿时间： | 2006-05-22 |
Determination of the particle size of porcine pulmonary surfactant lyophilized powder by laser scattering particle size distribution analysis |
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| YE Xiao - min, TIAN Song - jiu , LI Hui - yi , ZHANG Qi - ming.Determination of the particle size of porcine pulmonary surfactant lyophilized powder by laser scattering particle size distribution analysis[J].Chinese Journal of Pharmaceutical Analysis,2007,27(6):863-866. |
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| Authors: | YE Xiao - min TIAN Song - jiu LI Hui - yi ZHANG Qi - ming |
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| Affiliation: | 1. National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China; 2. Wuhan Institute for Drug Control, Wuhan 430012, China |
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| Abstract: | Objective:To develop a method for the determination of the particle size of porcine pulmonary surfactant lyophilized powder.Methods:Determine the particle size of the sample dispersed in 0.9% sodium chloride solution and in distilled water respectively and measure the Zeta potential to evaluate the stability of these two suspensions. Results:The sample is dispersed more effectively in distilled water.Conclusions:This method can be used for the determination of the particle size of the suspension of porcine pulmonary surfactant lyophilized powder and it is fast, simple and accurate. |
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| Keywords: | porcine pulmonary surfactant lyophilized powder laser scattering particle size distribution analysis Zeta potential |
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