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雷帕霉素联合环孢素预防肾移植急性排斥反应的随机对照前瞻性研究
引用本文:刘斌,明长生,曾凡军,张伟杰,陈知水,林正斌,刘敦贵.雷帕霉素联合环孢素预防肾移植急性排斥反应的随机对照前瞻性研究[J].中国药房,2006,17(13):1002-1004.
作者姓名:刘斌  明长生  曾凡军  张伟杰  陈知水  林正斌  刘敦贵
作者单位:华中科技大学同济医学院同济医院器官移植研究所,武汉市,430030
摘    要:目的:评价雷帕霉素(RPM)口服液联合环孢素(CsA)预防肾移植术后早期急性排斥反应的疗效。方法:首次肾移植患者20例,随机分成RPM试验组和硫唑嘌呤(Aza)对照组,每组各10例,分别接受以CsA和类固醇激素为基础的免疫抑制治疗方案6mo,比较2组人/肾存活率、急性排斥反应发生、不良事件发生等指标的差异。结果:17例完成治疗者人/肾均存活;仅Aza组1例发生2次急性排斥反应;2组各发生2例严重不良事件。结论:RPM联合CsA可有效预防移植肾急性排斥反应,并维持肾功能于良好水平,但是也可能增强CsA的肝毒性。

关 键 词:雷帕霉素  硫唑嘌呤  环孢素  肾移植  免疫抑制  排斥反应
文章编号:1001-0408(2006)13-1002-03
收稿时间:05 15 2006 12:00AM
修稿时间:05 30 2006 12:00AM

Rapamycin Combined with Cyclosporine in the Prevention of Acute Renal Allograft Rejection: Randomized Prospective Control Study
LIU Bin,MING Changsheng,ZENG Fanjun,ZHANG Weijie,CHEN Zhishui,LIN Zhengbin,LIU Dungui.Rapamycin Combined with Cyclosporine in the Prevention of Acute Renal Allograft Rejection: Randomized Prospective Control Study[J].China Pharmacy,2006,17(13):1002-1004.
Authors:LIU Bin  MING Changsheng  ZENG Fanjun  ZHANG Weijie  CHEN Zhishui  LIN Zhengbin  LIU Dungui
Affiliation:Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030,China
Abstract:OBJECTIVES:To evaluate the efficacy of rapamycin(RPM)oral liquid plus cyclosporine(CsA)on the prevenˉtion of early acute rejection after renal allograft.METHODS:20patients undergoing primary renal allografting were randomly divided into RPM trial group and Azathioprine(Aza)control group,10cases in each group,who were respectively assigned to receive CsA and adrenocortial hormones-based immunosuppression for6months,indexes including survival rates of recipients/kidneys,incidences of acute rejection and adverse reactions between2groups were compared.RESULTS:For the17patients who had finished6-month treatment,the survival rates(recipients/kidneys)were100%.Only2episodes of acute rejection occurred in one case in Aza group.Both groups had2cases of severe adverse episodes.CONCLUSIONS:The combined therapy pf RPM plus CsA is effective in the prevention of acute renal allograft rejection,and it can maintain renal function at a good level.Nevertheless,it may increase the hepatotoxicity of CsA.
Keywords:Rapamycin  Azathioprine  Ciclosporin  Renal transplantation  Immunosuppress  Rejection
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