| 2663例药物不良反应回顾性分析 |
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| 引用本文： | 杨晓华,李照文.2663例药物不良反应回顾性分析[J].中国药房,2000,11(2):81-82. |
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| 作者姓名： | 杨晓华 李照文 |
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| 作者单位： | 太原市中心医院!太原市030009 |
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| 摘 要： | 目的 :探讨药物不良反应的一般规律及各自特点 ,指导合理用药。方法 :用文献计量学方法对近10年国内公开报道的2663例药物不良反应进行回顾性分析。结果 :2663例药物不良反应中 ,抗生素引起的占46 19 % ,神经系统用药占15 92 % ,心血管系统用药占5 18 % ,血液及造血系统用药占1 76 % ,抗恶性肿瘤用药占1 99 %。2663例中死亡210例 ;青霉素占过敏性休克致死的30 16 % (19/63) ,别嘌呤醇占皮肤变态反应致死的40 % (12/30) ,庆大霉素占肾损害致死的47 82 % (11/23) ,复方新诺明占肝损害致死的27 22 % (5/18)。结论 :审慎用药 ,药物不良反应是可以大大减少的。
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| 关 键 词： | 药物不良反应 过敏性休克 皮肤变态反应 肾脏损害 |
A Retrospective Analysis of 2 663 Cases with Drug Adverse Reactions |
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| YANG Xiaohua,LI Zhaowen,ZHANG Fangxiang,QI Fuxiang.A Retrospective Analysis of 2 663 Cases with Drug Adverse Reactions[J].China Pharmacy,2000,11(2):81-82. |
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| Authors: | YANG Xiaohua LI Zhaowen ZHANG Fangxiang QI Fuxiang |
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| Abstract: | OBJECTIVE: To investigate the general rule and individual characteristics of drug adverse reactions(ADRs) so as to guide rational drug use METHODS: Using literature metrological analysis, 2 663 cases with ADRs ,reported in China during past 10 years,were retrospectively analyzed RESULTS: Among the 2 663 cases,46 19% was induced by antibiotics,25 92% by drugs for nervous diseases,5 18% by drugs for cardiovascular diseases,1 76% by drugs for hematological diseases and 1 99% by anticancer drugs Of the 2 663 cases, 210 died, among whom 30 16%(19/63) died of anaphylactic shock caused by penicillin,40 00%(12/30) died of dermal allergy to alloputinol,47 82%(11/23)died of renal dysfunction caused by gentamicin,27 22%(5/18) died of liver dysfunction caused by sulfamethoxazole CONCLUSION: We should pay attention to the rational use of drugs to reduce ADRs |
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| Keywords: | drugs adverse reaction anaphylactic shock dermal allergy renal dysfunction |
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