我国1990年～1999年中药不良反应的文献分析

目的 :对我国10年来 (1990年～1999年 )85种医药刊物中有关中药不良反应病例报道进行统计分析。方法 :用文献计量学方法 ,对1176例 (1291例次 )中药诱发ADRs报道进行回顾性调查研究 ,分析讨论诱发药物、症状表现、严重程度以及造成中药ADRs的原因。结果 :男女病例数为1∶1 15 ;诱发ADRs的药物涉及138个品种 ,其中以雷公藤片、双黄连注射液 (粉针 )和茵栀黄注射液为最 ,占27 96 % ;A类反应375例次 ,其中心血管系统损害比例最大 (19 73 % ) ;B类反应916例次 ,其中皮肤粘膜损害比例最大 (41 16 % ) ;造成重度损害者373例次 (28 89 % )。结论 :应加强有关中药安全用药知识的普及 ,规范临床合理应用中药及其制剂 ,实施对中药不良反应的控制、监测

Retrospective Analysis of Literature on ADRs of the Chinese Materia Medica Reported During 1990～1999

OBJECTIVE:To conduct statistical analysis on reports of ADRs of the Chinese materia medica published in 85 different kinds of journals during 1990～1999 METHODS:By the method of metrological analysis, we studied,retrospectively,1 176 cases with ADRs induced by Chinese materia medica and analyzed and discussed the reaction-inducing medicines,manifestations of symptoms,seriousness and the causes of ADRs RESULTS: The male:female ratio was 1∶1 15 Reaction-inducing medicines were up to 138; the most easily inducing ones were Tripterygium Glycodides tablet, Shuang Huanglian injection, Yin Zhihuang injection, amounting to 27 96% “A type”ADRs(toxic side reactions)amounted to 375, of which, cardiovascular system reactions accounted for 19 73%;“B type” ADRs(allergic reactions)amounted to 916, among which, cases of lesions on skin and mucous membrane were outstanding(up to 41 16%) Serious damage cases were 373(28 89%) CONCLUSION:The popularization of the knowledge on safe usage of Chinese materia medica should be reinforced; Rational clinical dosage of Chinese materia medica ought to be standardized and the ADRs induced by Chinese, materia medica have to be strictly supervised and controlled