| 原子吸收分光光度法测定注射用头孢他啶中助溶剂碳酸钠的含量 |
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| 引用本文： | 张冬,赫晓军,苑华,付焱.原子吸收分光光度法测定注射用头孢他啶中助溶剂碳酸钠的含量[J].中国药房,2011(5):447-448. |
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| 作者姓名： | 张冬 赫晓军 苑华 付焱 |
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| 作者单位： | 河北省药品检验所;河北医科大学; |
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| 摘 要： | 目的:建立测定注射用头孢他啶中助溶剂碳酸钠含量的方法。方法:采用原子吸收分光光度法。光源:钠空心阴极灯,原子化器:空气-乙炔火焰原子化器,分析线:330.3nm。结果:钠元素检测浓度线性范围为56.75～425.60μg·mL-(1r=0.9994);平均回收率为101.4%(RSD=3.2%),检出限为3.2μg·mL-1。结论:该方法灵敏度高、结果准确,可用于注射用头孢他啶中碳酸钠的含量测定。
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| 关 键 词： | 原子吸收分光光度法 注射用头孢他啶 碳酸钠 含量测定 |
Content Determination of Sodium Carbonate in Ceftazidime for Injection by Atomic Absorption Spectrophotometry |
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| ZHANG Dong,HE Xiao-jun,YUAN Hua FU Yan.Content Determination of Sodium Carbonate in Ceftazidime for Injection by Atomic Absorption Spectrophotometry[J].China Pharmacy,2011(5):447-448. |
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| Authors: | ZHANG Dong HE Xiao-jun YUAN Hua FU Yan |
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| Affiliation: | ZHANG Dong,HE Xiao-jun,YUAN Hua(Hebei Institute for Drug Control,Shijiazhuang 050011,China) FU Yan(Hebei Medical University,Shijiazhuang 050001,China) |
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| Abstract: | OBJECTIVE： To develop a method for the content determination of sodium carbonate in Ceftazidime for injection. METHODS： Atomic absorption spectrophotometery was adopted. Sodium hollow cathode lamp was used as light source, air-ethyne flame atomizer was used as atomizer, and analytical line was at 330.3 nm. RESULTS： The linear range of sodium was 56.75～425.60 μg·mL-1（r=0.999 4） with an average recovery of 101.4% （RSD=3.2%）. The limit of detection was 3.2 μg·mL-1. CONCLUSION： The method is sensitive, accurate and suitable for the content determination of sodium carbonate in Ceftazidime for injection. |
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| Keywords: | Atomic absorption spectrophotometry Ceftazidime for injection Sodium carbonate Content determination |
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