莪术油葡萄糖注射液与5种抗生素的配伍稳定性

目的 :观察莪术油葡萄糖注射液与5种常用抗生素配伍后的稳定性。方法 :用紫外分光光度法测定莪术油葡萄糖注射液中主成分莪术醇3h内含量的变化 ,同时观察配伍溶液的外观并测定其pH值。结果 :莪术油葡萄糖注射液与5种抗生素配伍后 ,样品液均无气体或沉淀产生 ;pH值随加入药物的不同而不同 ,但在3h内均无明显改变。与头孢哌酮钠配伍后莪术醇的含量下降最大 ,样品液为棕色 ;与头孢曲松钠配伍后含量下降亦较明显 ;与头孢拉定配伍后含量下降6 % ;与奈替米星和克林霉素配伍后含量和颜色均无改变。结论 :本品可与奈替米星、克林霉素配伍 ,但不宜与头孢哌酮钠、头孢曲松钠和头孢拉定配伍应用

The Stabilities of Zedoary Turmeric Oil and Glucose Injection Mixing With 5 Kinds of Antibiotics

OBJECTIVE:To observe the stabilities of zedoary turmeric oil and glucose injection mixing with 5 kinds of antibiotics METHODS:The contents of curcamol in mixed fluid were detected with UV spectrophotometry,and the external appearance and value of pH were observed RESULTS:After mixing zedoare turmeric oil and glucose injection with 5 kinds of antibiotics,no gas and sediment were found Values of pH were different in the 5 simples,and did not change markedly over 3 hours The concentration of curcumol was markedly reduced and the sample turned to brown in mixing with cefoperazone sodium;the concentration was declined in mixing with ceftriaxone sodium and decreased 6% with cefradine and was not markedly reduced in mixing with clindamycin and netilmicin CONCLUSION:This preparation is compatible with netilmicin and clindamycin,however,it is incompatible with cefoperazone and ceftriaxone