强肝胶囊治疗非酒精性脂肪性肝纤维化的疗效观察

目的:观察强肝胶囊治疗非酒精性脂肪性肝纤维化的疗效。方法:将28例非酒精性脂肪性肝病(NAFLD)患者随机分为2组。对照组12例进行基础护肝治疗,治疗组16例在对照组基础上口服强肝胶囊。2组疗程均为6个月。观察治疗前后2组患者的临床症状、肝功、血清肝纤维化指标、氧化应激指标、活检肝脏病理变化情况。结果:治疗组治疗后谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)、丙二醛(MDA)、玻璃酸(HA)、Ⅲ型前胶原肽(PcⅢ)、Ⅳ型胶原(ⅣC)、层黏蛋白(LN)、基质金属蛋白酶1组织抑制因子(TIMP-1)、病理组织评分与治疗前比较均有明显改善(P<0.01),与对照组治疗后比较差异有统计学意义(P<0.05)。结论:强肝胶囊可以改善肝脏炎症、促进肝内脂肪代谢、保护肝细胞,并对逆转肝纤维化有一定作用,是治疗NAFLD的有效药物之一。

Clinical Observation of Qianggan Capsule in the Treatment of Nonalcoholic Fatty Liver Fibrosis

OBJECTIVE:To observe the efficacy of Qianggan capsule in the treatment of nonalcoholic fatty liver.METHODS:28 patients with nonalcoholic fatty liver disease were randomly divided into experimental group (n=16) and control group (n=12).Both groups were given basic treatment of hepatoprotective drug for six months.Experimental group were treated with Qianggan capsule additionally.Clinical symptom,hepatic function,the biomarkers of oxidative stess,hepatic fibrosis indicators of 2 groups' before and after treat...