盐酸去氢骆驼蓬碱在人工胃液、肠液及蒸馏水中的稳定性考察

目的:考察盐酸去氢骆驼蓬碱在人工胃液、人工肠液及蒸馏水中的稳定性。方法:采用高效液相色谱法测定盐酸去氢骆驼蓬碱的含量,用经典恒温加速法考察温度对其在不同条件下稳定性的影响。结果:盐酸去氢骆驼蓬碱检测浓度的线性范围为1.8～30.0μg.mL-1,在人工胃液、人工肠液、蒸馏水中的降解符合一级动力学过程,预测的有效期分别为566、69、22d。结论:盐酸去氢骆驼蓬碱在人工胃液、人工肠液、蒸馏水中的稳定性均较好。

Stability of Harmine Hydrochloride in Artificial Gastric Juice, Intestinal Juice and Distilled Water

OBJECTIVE:To study the stability of harmine hydrochloride in artificial gastric juice,artificial intestinal juice and distilled water,respectively.METHODS:The content of harmine hydrochloride was determined by HPLC and the effect of temperature on the stability of harmine hydrochloride in artificial gastric juice,artificial intestinal juice and distilled water,respectively was detected by classic isothermal accelerated test.RESULTS:The linear range of harmine hydrochloride was 1.8～30.0μg·mL-1.The thermal degradation kinetics of harmine hydrochloride in artificial gastric juice,artificial intestinal juice and distilled water were in conformity with the first order kinetics.The expiration dates of harmine hydrochloride in artificial gastric juice,artificial intestinal juice and distilled water detected by classic isothermal accelerated tests were 566,69,and 22 days,respectively.CONCLUSION:The thermal stability of harmine hydrochloride in artificial gastric juice,artificial intestinal juice and distilled water were all satisfactory.