| 桑黄对四氯化碳致大鼠肝损伤的保护作用 |
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| 引用本文： | 张万国,胡晋红,蔡溱,黄瑾.桑黄对四氯化碳致大鼠肝损伤的保护作用[J].中国药房,2003,14(5):267-269. |
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| 作者姓名： | 张万国 胡晋红 蔡溱 黄瑾 |
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| 作者单位： | 第二军医大学长海医院药学部,上海市,200433 |
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| 摘 要： | 目的 :研究桑黄对肝损伤的保护作用。方法 :以四氯化碳诱导大鼠肝损伤 ,观察桑黄对血清学和组织学指标的影响。结果 :桑黄治疗组大鼠肝细胞变性明显减轻 ,肝组织结构完好 ;血清氨基酸转移酶水平显著降低 ,蛋白合成能力增强 ;血清活性氧显著减少 ,肝组织超氧化物歧化酶活力提高 ;血清白细胞介素 -4水平降低 ,γ -干扰素显著增高。结论 :桑黄具有保护肝细胞功能 ,抗脂质过氧化和调节炎症因子水平为其作用机理。
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| 关 键 词： | 桑黄 肝损伤 白细胞介素-4 γ-干扰素 |
| 文章编号： | 1001-0408(2003)05-0267-03 |
| 修稿时间： | 2002年5月9日 |
Protective Effect of Phellinus Igniarius on CCl4-induced Liver Injury in Rats |
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| ZHANG Wanguo,HU Jinhong,CAI Zhen,HUANG Jin.Protective Effect of Phellinus Igniarius on CCl4-induced Liver Injury in Rats[J].China Pharmacy,2003,14(5):267-269. |
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| Authors: | ZHANG Wanguo HU Jinhong CAI Zhen HUANG Jin |
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| Abstract: | OBJECTIVE:To study the protecting effect of Phellinus igniarius on liver injury.METHODS:Liver injury was induced by carbon tetrachloride in rats.Parameters of serum samples and tissue samples were analyzed to show the effect of Phellinus igniarius on liver injury.RESULTS:Degeneration of hepatocytes was obviously prevented in rats treated with Phellinus igniarius;the liver construction was well maintained.Phellinus igniarius could significantly decrease the serum levels of aminotransferase,active oxygen and IL-4,while increase the serum level of IFN-γand SOD activity in liver tisˉsue.CONCLUSION:Phellinus igniarius can protect hepatocytes from injury through anti-lipid peroxidation and regulating inflammatory factors. |
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| Keywords: | Phellinus igniarius liver injury interleukin-4 interferon-γ |
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