血清催乳激素水平与子宫肌瘤发病的相关性研究

目的 探讨子宫肌瘤的发生、发展与血清催乳激素（PRL）的关系。方法选择30例子宫肌瘤手术患者作为观察组，30例化脓性输卵管炎或输卵管积水行附件切除或子宫切除手术患者为对照组，两组于术前、术后3个月分别检测外周血PRL、雌二醇（E2）、孕酮（P）水平，观察两组血清PRL水平情况、观察组手术前后PRL水平变化及与术中子宫静脉血PRL水平情况。结果观察组外周静脉血中PRL为（1．17±0．65）nmol／L，对照组为（0．79±0．37）nmol／L，两组比较，差异有统计学意义（P〈0．05）；观察组术中外周静脉血PRL为（2．82±1．65）nmol／L，较术前升高，差异有统计学意义（P〈0．05），子宫静脉血PRL为（3．25±2．04）nmol／L、E，为（458．92±433．94）pmol／L，较外周静脉血明显升高，差异均有统计学意义（均P〈0．05）；术后3个月外周静脉血中PRL、E2较术前下降，差异有统计学意义（均P〈0．05）。结论PRL是子宫肌瘤自分泌或旁分泌的细胞因子，在子宫肌瘤的发生、发展中起了重要的作用。

Relationship between serum level of prolactin and uterine leiomyoma

Objective To studythe effects of prolacfin(PRL)on uterineleiomyoma and the relationship between prolactin and prolaetin receptor(PRL-R).Methods Thirty patients with uterine leiomyoma as observed group and thirty with hydrosalpinx or pyosalpingitis a8 control group were studied.Serum prolaetin(PrL),estradiol(E2)and progesterone(P)level were determinted by radioimmunoassay before,during and three months after hysterectomy in observed group and before salpingectomy in control group.Results Serum prolactin levd in observed group was signifieantly higher than that in control group(P＜0.05).The serunl prdactin level of uterine veins in obserced group was significantly higher than that ofperipheral vein' during hysterectomy(P＜0.05).The prolactin level during hysterectomy in observed group is significantly higher than that before hysterectomy(P＜0.05).Three months after hysterectomy the serum prolactin and estradiol level of peripheral vein in observed group was significantly decreased(P＜0.05).Conclusion Prolaetin is an autoerine or paraerine growth factor for human myometrial and leiomyoma cells.