基质金属蛋白酶-9基因在胃癌及癌旁组织中的表达及意义

目的探讨基质金属蛋白酶-9（MMP-9）基因在胃癌中的表达及其与临床病理因素之间的关系。方法采用免疫组织化学SP法检测97例胃癌组织及89例癌旁组织中MMP-9的表达。结果10例（11．2%）癌旁组织、80例（82．5%）胃癌组织表达MMP-9,差异有统计学意义（P=0．000）。MMP-9蛋白的过量表达与患者性别、肿瘤分级、分化和淋巴结转移无相关性,与肿瘤浸润深度、肿瘤分期存在相关性（P＜0．05）。结论MMP-9蛋白在胃癌中过量表达与胃癌的发生发展密切相关,可以作为胃癌的预后判断标准之一。

Overexpression of the matrix metalloproteinases-9 gene in gastric carcinoma

Objective To investigate the expression of matrix metalloproteinases-9(MMP-9)gene in gastric carcinoma(GC)and their relationship to clinicopathological factors.Methods Immunohistochemical staining SP method was used to detect the expression of MMP-9 in 97 cases of GC and 89 of paraearcinoma gastric mucosa tis- sue.Results The positive rate of MMP-9 expression was 11.2 %(10/89)in paracarcinoma gastric mucosa and 82.5 %(80/97)in GC specimens.There was significant difference between them(P=0.000).The expression of MMP-9 in GC was not correlated with the gender of patients,tumor differentiation,histological type and lymph node metastasis,but significantly associated with the depth of tumor invasinon and TNM staging.Conclusion Overex- pression of MMP-9 protein may play an important role in carcinogenesis and progession of gastric carcinoma.Detec- tion of the overexpression of MMP-9 might be served as an indicator for evaluating prognosis in gastric carcinoma.