来氟米特与环磷酰胺治疗狼疮肾炎的对照观察

目的比较来氟米特（LEF）和环磷酰胺（CTX）治疗狼疮肾炎（LN）的疗效、不良反应及安全性。方法43例活动性LN患者在使用激素的基础上随机分为两组，LEF组22例和CTX组21例，LEF组给予LEF20mg／d，半年为一疗程；CTX组间断给予CTX12mg·k^-1·d^-2加入10％葡萄糖注射液250ml中静脉滴注，每2周为一疗程，环磷酰胺总累计量控制在150mg／kg以内，随访6个月，监测血常规、血清白蛋白（Alb）、血肌酐（SCr）、ANA、ds—DNA、血24h尿蛋白定量、尿沉渣红细胞计数和白细胞计数和可能伴随的不良反应。结果治疗总有效率LEF组81．8％，CTX组85．7％，组间差异无统计学意义。不良反应CTX组13例（61．9％），LEF组3例（13．6％），组间差异有统计学意义。结论LEF治疗LN疗效与CTX相当，但其不良反应相对较轻，耐受性较好。

Controlled observation of ieflunomide and cyclophosphamide on lupus nephritis

Objective To compare the therapeutic effect, adverse effects and safety of leflunomide (LEF)and cyclophosphamide(CTX) on lupus nephritis(LN). Methods 43 patients with reactive LN were randomly divided into two groups. Based on hormone application,22 cases in LEF group were given LEF orally and 21 cases in CTX group were given CTX intravenous drip discontinuously. They were followed up for six months. The related indexes and possible concomitant adverse effects were detected. Results The total effective rate in LEF group was 81.8％ and that in CTX group was 85.7％. The tolerance in LEF group was better and 3 cases had adverse effects. 13 cases in CTX group had adverse effects. Conclusion LEF had the same efficacy as CTX in the LN therapy, but the tolerance is better and the side effects are minor than CTX.