多西紫杉醇联合奥沙利铂治疗进展期胃癌87例临床分析

目的评估多西紫杉醇联合奥沙利铂治疗进展期胃癌的效果和安全性。方法130例进展期胃癌患者随机分为实验组87例，对照组43例，实验组给予多西紫杉醇50mg／m^2静脉滴注，第1—3天；奥沙利铂65mg／m^2静脉滴注，第1天；氟脲嘧啶（5-Fu）500mg／m^2静脉滴注，第1～5天；亚叶酸钙（CF）300mg，第1～5天，在5-Fu之前2h静脉滴注。对照组用奥沙利铂130mg／m^2静脉滴注，第1天；5-Fu与CF的给药方法同实验组。3周为1个周期，治疗2个周期后评价疗效。结果实验组近期疗效、组织学变化、影像学变化等与对照组比较，差异均有统计学意义（均P〈0．05）。两组在白细胞减少、血小板减少、消化道反应、肝肾功能损害等不良反应方面比较，差异无统计学意义（均P〉0．05）。结论多西紫杉醇联合奥沙利铂化疗方案治疗进展期胃癌安全、有效。

Clinical analysis of docetaxel and oxaliplatin chemotherapy in 87 patients with advanced gastric cancer

Objective To evaluate the effect and toxicity of docetaxel combined with oxaliplatin,leucovorin and 5-fluorouracil regimen for patients with advanced gastric cancer,and compare with non-docetaxel chemotherapy regimen.Methods 130 patients with advanced gastric cancer were randomly divided into treatment group 87 patients and control group 43 patients.The regimen of the treatment groups was docetoxel 50mg/m2,iv infusion from day 1 to 3 ;oxaliplatin 65mg/m2,iv infusion on day 1 ;leucovofin 300mg/m2,iv infusion for 2 hours followed by 5-fluorouracil 500mg/m2,iv infusion from day 1 to 5.The regimen of the control group was oxaliplatin 130mg/m2,iv infusion on day 1.The usage of leucovorin and 5-fluorouracil were similar to the treatment group.All patients were evaluated after 2cycles( every cycle lasted 3 weeks).Results The effective rate in treatment group and in control group had statistical significance(P ＜ 0.05).The main to:deities were no statistical difference in two groups( P ＞ 0.05).Conclusion Docetoxel combined with oxaliplatin,leueovorin and 5-fluorouracil regimen is safe,high response and well tolerable for advanced gastric cancer.