依达拉奉对急性脑梗死患者超敏C-反应蛋白及D-二聚体的影响

目的探讨依达拉奉对急性脑梗死患者血清超敏C-反应蛋白（hs—CRP）、D-二聚体的影响及临床疗效。方法86例急性脑梗死患者随机分为两组，即常规治疗组和治疗组，治疗组在常规治疗基础上给予依达拉奉30mg每天2次静脉点滴，连用14d。治疗前后测定血清hs—CRP、D-二聚体的变化并用中国卒中量表（Chine sestroke scale，CSS）及巴氏指数（Barthel index，BI）评定。结果两组患者hs-CRP和D-二聚体均下降，治疗组明显低于常规治疗组（P〈0．05）。治疗后两组CSS及BI评分指数较治疗前均明显增加，治疗组评分高于常规治疗组（P〈0．05）。结论依达拉奉可降低急性脑梗死患者hs-CRP、D-二聚体的水平，有益于患者神经功能的恢复。

Effects of Edaravone on the levels of hs-CRP and D-dimer in Patients with Acute Cerebral infarction

Objective To investigate the effects of edaravone on the levels of high sensitivity C-reactive protein(hs-CRP) and D-dimer in patients with acute ischemic cerebral infarction. Methods A total of 86 patients with acute ischemic cerebral infarction were randomly divided and assigned into therapy group and control group. The control group was given a routine treatment of acute ischemic stroke. The therapy group was treated with edaravone in addition to the routine treatment. hs-CRP and D-dimer were measured before and after treatment. Barthel index(BI) and Chinese stroke Scale(CSS) of two groups were assessed before treatment and after treatment. Results The levels of hs-CRP and D-dimer were deceased after treatment. After the start of edaravone ,the levels of hs-CRP and D-dimer of therapy group were significantly lower than those of control group(P ＜0.05). The scores of CSS and BI of two groups improved after treatment,and scores of CSS and BI of the therapy group were better than those of the control group(P＜ 0.05). Conclusion Edaravone could decrease the levels of hs-CRP and D-dimer and is beneficial to improve neurofunctional recovery.