1,6-二磷酸果糖镁对异丙肾上腺素所致大鼠心肌损伤的保护作用

研究1,6-二磷酸果糖镁（FDP-Mg）对异丙肾上腺素（Iso）所致心肌损伤的保护作用. 大鼠sc Iso (8 mg·kg^-1·d^-1, 3 d)造成心肌损伤模型，测定心肌组织和血清肌酸激酶（CK）, 乳酸脱氢酶（LDH）, 超氧化物歧化酶（SOD）活性及丙二醛（MDA）, Mg²⁺, P和K⁺含量. 结果：每天给予Iso的同时给予FDP-Mg（250-1000 mg·kg^-1·d^-1, 3 d）能明显降低血清CK，LDH水平，抑制心肌组织中CK，LDH释放，提高血清和心肌SOD活性，降低MDA水平，提高心肌及血清Mg²⁺和P含量，降低血清K⁺浓度。综合了FDP-Na₂（530 mg·kg^-1·d^-1, 3 d）和硫酸镁（150 mg·kg^-1·d^-1, 3 d）的作用特点。结果表明，FDP-Mg对Iso所致大鼠心肌损伤具有保护作用，与其抗氧化及改善心肌代谢有关.

Effects of magnesium fructose-1,6-diphosphate on myocardial lesion induced by isoproterenol in rats

Effects of magnesium fructose-1,6-diphosphate(FDP-Mg) on myocardial lesion induced by isoprenaline(Iso) in rats were studied. The models of myocardial lesion were made by sc Iso 8 mg·kg^-1·d^-1 for 3 days. Levels of creatin kinase(CK), lactate dehydrogenase(LDH), superoxide dismutase(SOD), and contents of malondialdehyde(MDA), Mg²⁺, P and K⁺ in the myocardium and the serum were determined. By dose-dependent fashion，250-1000 mg·kg^-1 FDP- Mg, given iv immediately after each sc Iso, reduced the levels of CK, LDH, K⁺ in serum, depressed the release of CK, LDH from myocardium, enhanced activity of SOD and contents of Mg²⁺, P in myocardium and serum, reduced the content of MDA in myocardium and serum. The results showed that FDP-Mg had similar action characteristics of both FDP-Na₂ (5-30 mg·kg^-1·d^-1, 3 d) and MgSO₄(150 mg·kg^-1, 3 d), which suggest that FDP- Mg have the protective effect against myocardial lesion produced by isoprote renol in rats. Its action relates to anti- oxidation and improvement of myocardial metabolism.