鱼腥草的有效成分甲基正壬基酮及其作用机制

目的研究鱼腥草的有效成分及其作用机制。方法采用GC/MS法分析鱼腥草挥发油的组分;利用KM小鼠比较鱼腥草素钠及癸酰乙醛分解产物甲基正壬基酮的免疫增强作用,结果在鱼腥草挥发油中除甲基正壬基酮外未发现其他癸酰乙醛的分解产物。甲基正壬基酮和鱼腥草素钠有免疫增强作用。两者都能显著增强血清溶血素水平、迟发型超敏反应强度、巨噬细胞吞噬功能及NK细胞活性,显著增加脾空斑数及显著抑制巴豆油所致耳的肿胀。结论癸酰乙醛是前体,甲基正壬基酮是鱼腥草的有效成分,具有免疫增强作用。

Methyl n-nonylketone as an active principle of Herba Houttuyniae and its mechanism

A/M To investigate the active principle of Herba Houttuyniae and its mechanism. METHODS The chemical constituents of essential oil from Herba Houttuyniae were analyzed by GC/MS method. The inmmnopotentiating effects between sodium houttuyfonate and decanoyl acetaldehyde decomposition product were compared. RESULTS None of decomposition of decanoyl acetaldehyde in essential oil from Herba Houttuyniae were discovered in addition to methyl n-nonylketone. Sodium houtmyfonate and methyl n-nonyl ketone possessed immunopotentiating effects. Both of them can significantly strengthen the serum hemolysin, the delayed type of hypersensitivity reaction , the phagocytosing function of the macrophage and the activity of the NK cell. Both of them significantly enhanced the production of the spleen plaque forming cell （PFC） , significantly suppressed the ear edema degree induced by croton oil. CONCLUSION The experimental data indicate the decanoyl acetaldehyde is a precursor. The decanoyl acetaldehyde decomposition product, methyl n-nonylketone, is an active principle of Herba Houttuyniae ,and it possesses irranunopotentiating effect useful in acute and chronic infectious diseases.