| Affiliation: | 1. Centre for Nanoscience and Technology, A.C. Tech Campus, Anna University, India;2. International Institute of Biotechnology and Toxicology (IIBAT), Padappai, India;3. Alternative Energy and Nanotechnology Laboratory (AENL), Nanofunctional Materials Technology Centre (NFMTC), Department of Physics, Indian Institute of Technology Madras, Chennai, India |
| Abstract: | Human beings and ecosystems are being possibly exposed to CNTs, as there is a rise in global production rate of carbon nanotubes (CNTs). This may affect the health of humans and increases the environmental risk. We have already reported the pulmonary toxicity due to the inhalation of MWCNTs. We claim that a compound with anti-inflammatory and antioxidant activity may ameliorate the CNT-induced toxic effect. With this view, we have investigated the ameliorative effect of intravenously-administered nano bis-demethoxy curcumin analog (NBDMCA) against MWCNTs-induced inhalation toxicity by examining the lung histopathology for inflammatory cell dynamics, pulmonary remodeling and estimating the inflammatory biomarkers in the broncho-alveolar lavage fluid. We observed that NBDMCA could ameliorate the injury as evidenced by the decline in the levels of markers of inflammation, cell damage, and the histopathological changes induced by MWCNTs. We conclude that NBDMCA may be used to reduce the risk of MWCNTs-induced inhalation toxicity. |
