开喉剑喷雾剂联合肿痛安胶囊治疗儿童疱疹性口腔炎的临床研究

目的探讨开喉剑喷雾剂联合肿痛安胶囊治疗儿童疱疹性口腔炎的临床效果。方法选择北京怀柔医院2015年3月—2017年6月就诊的儿童疱疹性口腔炎患儿92例为研究对象,随机分为对照组和治疗组,每组各46例。对照组患者外敷肿痛安胶囊,将1粒肿痛安胶囊中的药粉以少量香油调成糊状,无菌棉签蘸取敷于创面,同时口服肿痛安胶囊,2粒/次,3次/d。治疗组在对照组的基础上将开喉剑喷雾剂喷于患处,2喷/次,4~5次/d。开喉剑喷雾剂与肿痛安胶囊外敷间隔1 h。两组均连续治疗1周。治疗后,观察两组患者的临床疗效,比较两组症状体征缓解时间和外周血白细胞计数(WBC)、血清C反应蛋白(CRP)水平。结果治疗后,对照组和治疗组的总有效率分别为78.26%、95.65%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组退热时间、疼痛、流涎消失时间、溃疡消退时间、进食恢复时间均显著短于对照组,两组比较差异具有统计学意义(P0.05)。两组外周血WBC和血清CRP水平均较治疗前明显降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗后治疗组外周血WBC、血清CRP水平均显著低于对照组,两组比较差异具有统计学意义(P0.05)。结论开喉剑喷雾剂联合肿痛安胶囊治疗儿童疱疹性口腔炎疗效显著,可迅速缓解患儿疼痛、流涎、溃疡等症状,促进炎症反应的缓解,安全性高,具有一定的临床推广应用价值。

Clinical study on Kaihoujian Spray combined with Zhongtong'an Capsules in treatment of herpes stomatitis in children

Objective To investigate the clinical effect of Kaihoujian Spray combined with Zhongtong''an Capsules in treatment of herpes stomatitis in children. Methods Patients (92 cases) with herpes stomatitis in children in Beijing Huairou Hospital from March 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were given 1 grain of Zhongtong''an Capsules. The powder was made a paste with a small amount of sesame oil, and was applied to the wound. At the same time, patients in the control group were po administered with Zhongtong''an Capsules, 2 grains/time, three times daily. Patients in the treatment group were given Kaihoujian Spray, 2 sprays/time, 4-5 times/d. The use of Kaihoujian Spray and external application of Zhongtong''an Capsules had an interval of 1 h. Patients in two groups were treated for 1 week. After treatment, the clinical efficacies were evaluated, and response duration of symptoms and signs, WBC, and CRP levels in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 78.26% and 95.65%, respectively, and there was difference between two groups (P < 0.05). After treatment, fever clearance time, disappearance time of pain, salivation, and ulceration, and feeding recovery time were shorter than those in the control group, and there was difference between two groups (P < 0.05). WBC level in peripheral blood and CRP level in serum in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And WBC and CRP levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Kaihoujian Spray combined with Zhongtong''an Capsules has good effect in treatment of herpes stomatitis in children, can quickly relieve pain, salivation, ulcers and other symptoms, and promote the relief of inflammatory response with high safety, which has a certain clinical application value.