2014—2018年天津市肿瘤医院门诊麻醉性镇痛药的使用情况分析

目的分析2014—2018年天津市肿瘤医院门诊麻醉性镇痛药的使用情况,为临床合理使用提供参考。方法调取天津市肿瘤医院2014—2018年门诊麻醉性镇痛药的用药相关信息,对药物剂型、使用金额、用药频度(DDDs)、日均费用(DDC)及药品排序比(B/A)进行统计分析。结果 2014—2018年门诊麻醉性镇痛药中,口服剂型的使用金额和DDDs的构成比逐年上涨,透皮贴剂和注射剂使用金额和DDDs的构成比呈下降趋势。硫酸吗啡缓释片30mg的DDDs排名一直居于首位,羟考酮缓释片10mg在2016年后上升至第2位,羟考酮缓释片40mg排名大幅上升,芬太尼透皮贴剂8.4mg的DDDs排名出现明显下降。2016—2017年各麻醉性镇痛药的DDC开始略有下降。各药品的B/A略有变化,均接近1,表明使用金额与使用频度的同步性较好。结论天津市肿瘤医院麻醉性镇痛药的使用合理,符合安全、有效、方便的原则。

Analysis on utilization of narcotic analgesics in the outpatients of Tianjin Cancer Hospital from 2014 to 2018

Objective To investigate the utilization of narcotic analgesics in the outpatients of Tianjin Cancer Hospital from 2014 to 2018. Methods The utilization information of narcotic analgesics in the outpatients of Tianjin Cancer Hospital from 2014 to 2018 was extracted, and the dosage form of drugs, consumption sum, defined daily doses (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) were analyzed statistically. Results From 2014 to 2018, the consumption and DDDs constituent ratios of oral formulations had increased sharply. The consumption and DDDs constituent ratios of transdermal patches and injections had been on a downward trend. In the past five years, the DDDs of morphine sulfate sustained release tablet (30 mg) led the list. By 2016, the DDDs of Oxycodone Sustained-release Tablets (10 mg) ranked the second. DDDs of Oxycodone Sustained-release Tablets (40 mg) increased significantly, while Fentanyl Transdermal Patches (8.4 mg) declined obviously. DDC of various narcotic analgesics began to decline slightly from 2016 to 2017. B/A of most fluorouracil drugs closed to 1.00, indicating that the synchronism was better. Conclusion The utilization of narcotic analgesics in Tianjin Cancer Hospital is reasonable, accords with the principle of safety, effectiveness and convenience.