盐酸二甲双胍在正常大鼠与糖尿病大鼠体内的药动学比较

目的比较盐酸二甲双胍在正常大鼠与糖尿病大鼠体内的药动学差异。方法正常大鼠与糖尿病模型大鼠,分别灌胃给予盐酸二甲双胍后,于不同时间点采集血样,用HPLC测定血药浓度并绘制药-时曲线,用DAS1.0统计软件计算药动学参数。结果盐酸二甲双胍在正常大鼠与糖尿病大鼠体内的主要药动学参数分别为：Cmax=9.41μg·mL^-1、t1/2=161.8min、Cl/F=0.079L·min^-1·kg^-1;Cmax=20.09μg·mL^-1、t1/2=1718.93min、Cl/F=0.012L·min^-1·kg^-1。结论盐酸二甲双胍在正常大鼠与糖尿病模型大鼠体内的药动学参数有明显差异（P〈0.05）。

Comparison on the Pharmacokinetic of Metformin Hydrochloride between Normal and Diabetic Rats

OBJECTIVE To compare the pharmacokinetic differences of metformin hydrochloride between normal and diabetic rats. METHODS Metformin hydrochloride was orally administrated to the normal and diabetic rats. The blood samples were collected at different time. The concentration of metformin hydrochloride in plasma was determined by HPLC method. The software of DAS 1.0 was used to estimate the pharmacokinetic parameters. RESULTS The main pharmacokinetic parameters of metformin hydrochloride in normal and diabetic rats were Cmax=9.41 μg·mL^-1, t1/2=161.8 min, C1/F=0.079 L·min^-1·kg^-1 and Cmax=20.09 μg·mL^-1, t1/2 =1 718.93 min, CI/F=0.012 L·min^-1·kg^-1, respectively. CONCLUSION The main pharmacokinetic parameters of metformin hydrochloride in normal and diabetic rats have significant differences （P〈0.05）.